Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.53 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.36 |
| ▸ | DHPS | P49366 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18166335 | 0.90 | P2RX3 (0.59) | P2RX3P2RX2PTK2TDP1HSD11B1 | |
| SCHEMBL10244599 | 0.87 | P2RX3 (0.68) | P2RX3P2RX2ROCK2DHPSMAPK1 | |
| SCHEMBL18036457 | 0.84 | P2RX3 (0.53) | P2RX3P2RX2MAPTGAAALDH1A1 | |
| SCHEMBL18036400 | 0.84 | P2RX3 (0.53) | P2RX3P2RX2MAPTGAAALDH1A1 | |
| SCHEMBL18166332 | 0.83 | EPHX1 (0.52) | P2RX3P2RX2POLBKDM4EMAPT | |
| SCHEMBL18166293 | 0.82 | P2RX3 (0.57) | P2RX3P2RX2ROCK2MAPK1ALDH1A1 | |
| SCHEMBL18036359 | 0.82 | P2RX3 (0.52) | P2RX3P2RX2MAPTGAAALDH1A1 | |
| SCHEMBL18036312 | 0.82 | P2RX3 (0.57) | P2RX3P2RX2MAPTALDH1A1NPSR1 | |
| SCHEMBL18166334 | 0.81 | P2RX3 (0.77) | P2RX3P2RX2 | |
| SCHEMBL18166326 | 0.81 | P2RX3 (0.77) | P2RX3P2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038264-B1 | TETRAZOLE-SUBSTITUTED ARYLAMIDES | HOFFMANN LA ROCHE (CH) | 2016-10-26 | — | — | EP | claimed |