Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 6/20 | 0.61 |
| ▸ | TP53 | P04637 | 4/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.54 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1067104 | 0.89 | CYP1A2 (0.69) | RXFP1TP53MAPK1CYP1A2CYP3A4 | |
| SCHEMBL1063738 | 0.88 | RXFP1 (0.61) | RXFP1TP53MAPK1CYP1A2CYP3A4 | |
| SCHEMBL1065506 | 0.88 | TP53 (0.64) | RXFP1TP53MAPK1CYP1A2CYP3A4 | |
| SCHEMBL1064143 | 0.86 | CYP1A2 (0.72) | RXFP1TP53MAPK1CYP1A2CYP3A4 | |
| SCHEMBL20161764 | 0.85 | CYP1A2 (0.71) | RXFP1TP53MAPK1CYP1A2CYP3A4 | |
| SCHEMBL18166598 | 0.84 | RXFP1 (0.71) | RXFP1TP53MAPK1CYP1A2CYP3A4 | |
| SCHEMBL5462777 | 0.84 | RXFP1 (0.78) | RXFP1TP53MAPK1CYP1A2CYP3A4 | |
| SCHEMBL18166737 | 0.84 | CYP1A2 (0.71) | RXFP1TP53MAPK1CYP1A2CYP3A4 | |
| SCHEMBL10113988 | 0.83 | RXFP1 (0.62) | RXFP1TP53MAPK1CYP1A2CYP3A4 | |
| SCHEMBL18166590 | 0.82 | CYP1A2 (0.69) | RXFP1TP53MAPK1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3663295-A1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | ELI LILLY AND CO. (US) | 2020-06-10 | — | — | EP | disclosed |
| EP-3184527-A1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | Hydra Biosciences, Inc. (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-2170309-B1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | HYDRA BIOSCIENCES INC (US) | 2016-10-26 | — | — | EP | disclosed |