SCHEMBL18166647

SCHEMBL18166647

Cn1c(=O)c2c(ncn2CC(=O)NCCc2ccc(OCc3ccccc3)cc2)n(C)c1=O

nearest known ligand 0.66

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.66
CYP3A4 P08684 1/20 0.66
RXFP1 Q9HBX9 3/20 0.59
MAPK1 P28482 2/20 0.59
TP53 P04637 2/20 0.59
LMNA P02545 2/20 0.58
GAA P10253 1/20 0.58
ALDH1A1 P00352 4/20 0.57
HSD17B10 Q99714 2/20 0.55
TSHR P16473 2/20 0.55
ALOX15 P16050 1/20 0.55
SMN1; SMN2 Q16637 2/20 0.53
ADORA2B P29275 1/20 0.53
NPSR1 Q6W5P4 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20161764 0.92 CYP1A2 (0.71) CYP1A2CYP3A4RXFP1MAPK1TP53
SCHEMBL18166590 0.88 CYP1A2 (0.69) CYP1A2CYP3A4RXFP1MAPK1TP53
SCHEMBL1065336 0.88 CYP1A2 (0.78) CYP1A2CYP3A4RXFP1MAPK1TP53
SCHEMBL18166693 0.87 CYP1A2 (0.68) CYP1A2CYP3A4RXFP1MAPK1TP53
SCHEMBL10113917 0.86 RXFP1 (0.68) CYP1A2RXFP1TP53GAAALDH1A1
SCHEMBL18166736 0.85 CYP1A2 (0.72) CYP1A2CYP3A4RXFP1MAPK1TP53
SCHEMBL1060801 0.85 CYP1A2 (0.72) CYP1A2CYP3A4RXFP1MAPK1TP53
SCHEMBL1066761 0.84 CYP1A2 (0.71) CYP1A2CYP3A4RXFP1MAPK1TP53
SCHEMBL18166737 0.84 CYP1A2 (0.71) CYP1A2CYP3A4RXFP1MAPK1TP53
SCHEMBL18166663 0.83 CYP1A2 (0.71) CYP1A2CYP3A4RXFP1MAPK1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3663295-A1 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL ELI LILLY AND CO. (US) 2020-06-10 EP disclosed
EP-3184527-A1 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL Hydra Biosciences, Inc. (US) 2017-06-28 EP disclosed
EP-2170309-B1 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL HYDRA BIOSCIENCES INC (US) 2016-10-26 EP disclosed