Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18167157 | 0.89 | PIK3CG (0.46) | PIK3CGMAPTSHMT2KDM4EGAA | |
| SCHEMBL18167163 | 0.87 | PIK3CG (0.44) | PIK3CGMAPTBRD4 | |
| SCHEMBL18167162 | 0.86 | PIK3CG (0.44) | PIK3CGMAPTBRD4 | |
| SCHEMBL18167148 | 0.86 | MAPT (0.38) | PIK3CGMAPTKDM4EMAPK1PIK3CD | |
| SCHEMBL15192968 | 0.85 | PIK3CG (0.42) | PIK3CGMAPTSHMT2KDM4EGAA | |
| SCHEMBL15193666 | 0.85 | MAPT (0.39) | PIK3CGMAPTTHRBSHMT2KDM4E | |
| SCHEMBL18167149 | 0.85 | PIK3CG (0.38) | PIK3CGMAPTTHRBSHMT2KDM4E | |
| SCHEMBL18167151 | 0.85 | PIK3CG (0.38) | PIK3CGMAPTTHRBSHMT2KDM4E | |
| SCHEMBL18167159 | 0.85 | PIK3CG (0.46) | PIK3CGMAPT | |
| SCHEMBL15192985 | 0.85 | MAPT (0.46) | PIK3CGMAPTTHRBSHMT2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2630129-B1 | QUINOXALINE DERIVATES | MERCK PATENT GMBH (DE) | 2016-10-26 | — | — | EP | claimed |