Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18167158 | 0.88 | PIK3CG (0.46) | PIK3CGKMT2A | |
| SCHEMBL18167165 | 0.87 | PIK3CG (0.45) | NPC1RAB9APIK3CGKMT2A | |
| SCHEMBL18167151 | 0.87 | PIK3CG (0.38) | MAPTPIK3CGPIK3CDKMT2AKDM4E | |
| SCHEMBL18167164 | 0.86 | PIK3CG (0.44) | PIK3CGKMT2A | |
| SCHEMBL18167150 | 0.84 | TLR8 (0.39) | NPC1RAB9AMAPTALDH1A1HPGD | |
| SCHEMBL15192969 | 0.84 | PIK3CG (0.41) | NPC1RAB9AMAPTPIK3CGKMT2A | |
| SCHEMBL15193671 | 0.84 | NPC1 (0.39) | NPC1RAB9AMAPTALDH1A1HPGD | |
| SCHEMBL18167156 | 0.83 | PIK3CG (0.49) | MAPTPIK3CGPIK3CDKMT2A | |
| SCHEMBL15192988 | 0.83 | MAPT (0.46) | NPC1RAB9AMAPTALDH1A1HPGD | |
| SCHEMBL18167148 | 0.82 | MAPT (0.38) | NPC1RAB9AMAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2630129-B1 | QUINOXALINE DERIVATES | MERCK PATENT GMBH (DE) | 2016-10-26 | — | — | EP | claimed |