Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 4/20 | 0.61 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.50 |
| ▸ | NUDT1 | P36639 | 6/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29541092 | 0.81 | PRKCI (0.65) | PRKCIGRM4NUDT1AURKBALK | |
| SCHEMBL101483 | 0.81 | PRKCI (0.65) | PRKCIGRM4NUDT1AURKBALK | |
| SCHEMBL13774670 | 0.76 | PRKCI (0.70) | PRKCIGRM4NUDT1AURKBCCNK | |
| SCHEMBL99352 | 0.76 | PRKCI (1.00) | PRKCIGRM4NUDT1AURKBALK | |
| SCHEMBL99235 | 0.76 | PRKCI (0.58) | PRKCIGRM4NUDT1AURKBALK | |
| SCHEMBL22930948 | 0.75 | PRKCI (0.65) | PRKCIGRM4NUDT1AURKBCCNK | |
| SCHEMBL12330454 | 0.75 | PRKCI (0.57) | PRKCIGRM4NUDT1AURKBALK | |
| SCHEMBL3453092 | 0.74 | PRKCI (0.67) | PRKCIGRM4NUDT1AURKBALK | |
| SCHEMBL102315 | 0.73 | PRKCI (0.62) | PRKCIGRM4NUDT1AURKBALK | |
| SCHEMBL29540824 | 0.73 | PRKCI (0.62) | PRKCIGRM4NUDT1AURKBALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2455382-B1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE HOLDINGS CORP (US) | 2016-10-26 | — | — | EP | disclosed |