Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 3/20 | 0.65 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.45 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | CCNK | O75909 | 6/20 | 0.44 |
| ▸ | CDK12 | Q9NYV4 | 6/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 5/20 | 0.42 |
| ▸ | AKT2 | P31751 | 3/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3453092 | 0.88 | PRKCI (0.67) | PRKCIAURKAAURKBINCENPTPX2 | |
| SCHEMBL13774670 | 0.82 | PRKCI (0.70) | PRKCIAURKAAURKBINCENPTPX2 | |
| SCHEMBL99352 | 0.79 | PRKCI (1.00) | PRKCIAURKAAURKBINCENPTPX2 | |
| SCHEMBL98790 | 0.78 | NUDT1 (0.58) | PRKCIAURKAAURKBINCENPTPX2 | |
| SCHEMBL27741956 | 0.78 | PRKCI (0.65) | PRKCIAURKAAURKBINCENPTPX2 | |
| SCHEMBL102287 | 0.77 | PRKCI (0.53) | PRKCIAURKAAURKBINCENPTPX2 | |
| SCHEMBL29541478 | 0.77 | PRKCI (0.53) | PRKCIAURKAAURKBINCENPTPX2 | |
| SCHEMBL29541092 | 0.76 | PRKCI (0.65) | PRKCIAURKAAURKBINCENPTPX2 | |
| SCHEMBL101483 | 0.76 | PRKCI (0.65) | PRKCIAURKAAURKBINCENPTPX2 | |
| SCHEMBL18167340 | 0.75 | PRKCI (0.61) | PRKCIAURKAAURKBINCENPTPX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466953-B1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | INCYTE HOLDINGS CORP (US) | 2021-02-03 | — | — | EP | disclosed |