Clopipazan

Clopipazan

SCHEMBL1816896

CN1CCC(=C2c3ccccc3Oc3ccc(Cl)cc32)CC1

nearest known ligand 0.76

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SETD7 Q8WTS6 5/20 0.76
DRD2 P14416 6/20 0.55
DRD4 P21917 5/20 0.55
CYP2D6 P10635 4/20 0.55
CYP2C19 P33261 3/20 0.55
CYP1A2 P05177 3/20 0.55
TP53 P04637 2/20 0.55
MAPT P10636 2/20 0.55
CYP3A4 P08684 2/20 0.55
TDP1 Q9NUW8 1/20 0.55
HRH4 Q9H3N8 4/20 0.54
HRH1 P35367 4/20 0.54
CHRM2 P08172 4/20 0.54
HTR1A P08908 4/20 0.54
ADRA2A P08913 4/20 0.54
DRD1 P21728 4/20 0.54
SLC6A2 P23975 4/20 0.54
SLC6A4 P31645 4/20 0.54
ADRA1A P35348 4/20 0.54
DRD3 P35462 4/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Clopipazan SCHEMBL120732 0.92 SETD7 (0.64) SETD7DRD2DRD4CYP2D6CYP2C19
Clopipazan SCHEMBL11573664 0.90 SETD7 (0.61) SETD7DRD2DRD4CYP2D6CYP2C19
Clopipazan SCHEMBL11573662 0.90 SETD7 (0.61) SETD7DRD2DRD4CYP2D6CYP2C19
SCHEMBL5905710 0.87 SETD7 (1.00) SETD7DRD2DRD4CYP2D6CYP2C19
SCHEMBL11576476 0.86 SETD7 (0.56) SETD7DRD2DRD4CYP2D6CYP2C19
SCHEMBL11576057 0.86 SETD7 (0.55) SETD7DRD2DRD4CYP2D6CYP2C19
Hydrochloric Acid SCHEMBL11576452 0.85 SETD7 (0.54) SETD7DRD2DRD4CYP2D6CYP2C19
SCHEMBL11572834 0.84 SETD7 (0.56) SETD7DRD2DRD4CYP2D6CYP2C19
SCHEMBL11573091 0.84 SETD7 (0.76) SETD7DRD2DRD4CYP2D6CYP2C19
SCHEMBL11576560 0.84 SETD7 (0.76) SETD7DRD2DRD4CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 133 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1931320-B1 MICROPARTICLES WITH MODIFIED RELEASE OF AT LEAST ONE ACTIVE PRINCIPLE AND ORAL DOSAGE FORM COMPRISING THE SAME FLAMEL IRELAND LTD (IE) 2022-06-15 EP claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
US-20090220611-A1 Microparticles With Modified Release of At Least One Active Principle and Oral Pharmaceutical Form Comprising Same FLAMEL TECHNOLOGIES, S.A. (FR) 2009-09-03 US claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
EP-1044023-B1 A COVALENT CONJUGATE OF CLOZAPINE WITH A FATTY ACID AND ITS USE FOR TREATING SCHIZOPHRENIA LUITPOLD PHARM INC (US) 2005-05-25 EP claimed
US-4086350-A FLUORO, CHLORO AND CYANO SUBSTITUTED 4-(9-XANTHENYLIDENE, 9-THIOXANTHENYLIDENE OR 11(6H)-DIBENZO(B,E)OXEPINYLIDENE)-1-METHYL-PIPERIDINES SMITHKLINE CORPORATION (US) 1978-04-25 US claimed
EP-4031114-A1 METHODS OF TREATING EPILEPTIC PATIENTS WITH FENFLURAMINE Zogenix International Limited (GB) 2022-07-27 EP disclosed
US-11389453-B2 Compositions and methods for treating chemosensory dysfunction CYRANO THERAPEUTICS, INC. (US) 2022-07-19 US disclosed
US-20220047505-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2022-02-17 US disclosed
US-11191719-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2021-12-07 US disclosed
US-20210137853-A1 METHODS OF TREATING EPILEPTIC PATIENTS WITH FENFLURAMINE ZOGENIX INTERNATIONAL LIMITED (GB) 2021-05-13 US disclosed
US-20020102215-A1 Diagnostic/therapeutic agents NYCOMED IMAGING AS 2002-08-01 US disclosed
WO-2002045693-A1 PHARMACEUTICAL PREPARATION COMPRISING AN ACTIVE DISPERSED ON A MATRIX ALTANA PHARMA AG (DE) 2002-06-13 WO disclosed
US-6331289-B1 ULTRASOUND CONTRAST AGENTS, SUSPENSION IN AQUEOUS CARRIER LIQUID OF A REPORTER COMPRISING GAS-CONTAINING OR GAS-GENERATING MATERIAL, AGENT CAPABLE OF FORMING AT LEAST TWO TYPES OF BINDING PAIRS WITH TARGET; REPORTER BEING CONJUGATED NYCOMED IMAGING AS (NO) 2001-12-18 US disclosed
US-6264917-B1 MIXTURE OF GAS FILLED MICROBUBBLES AND RELEASING AGENT NYCOMED IMAGING AS (NO) 2001-07-24 US disclosed
US-6261537-B1 TARGETS AND ULTRASOUND DIAGNOSIS OF ACTIVE MATERIALS, AQUEOUS CARRIER LIQUIDS, CARRIERS AND FILM FORMING SURFACTANT PHOSPHATIDES NYCOMED IMAGING AS (NO) 2001-07-17 US disclosed
US-4086350-A FLUORO, CHLORO AND CYANO SUBSTITUTED 4-(9-XANTHENYLIDENE, 9-THIOXANTHENYLIDENE OR 11(6H)-DIBENZO(B,E)OXEPINYLIDENE)-1-METHYL-PIPERIDINES SMITHKLINE CORPORATION (US) 1978-04-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210137853-A1 METHODS OF TREATING EPILEPTIC PATIENTS WITH FENFLURAMINE SLC6A4, SLC1A2, SLC6A2 SETD7 1563/4885DRD2 172/4885DRD4 361/4885
US-20020102215-A1 Diagnostic/therapeutic agents BID, FUS, FABP1 SETD7 4240/4885DRD2 4727/4885DRD4 4704/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.