Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Ethylisothiourea. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylisothiourea SCHEMBL160501 | 0.97 | — | — | |
| Ethylisothiourea SCHEMBL6837679 | 0.94 | — | — | |
| Ethylisothiourea SCHEMBL2916536 | 0.94 | — | — | |
| Ethylisothiourea SCHEMBL16322930 | 0.91 | — | — | |
| Ethylisothiourea SCHEMBL7418298 | 0.91 | — | — | |
| Ethylisothiourea SCHEMBL31563742 | 0.84 | NOS1 (0.75) | — | |
| Ethylisothiourea SCHEMBL4409267 | 0.84 | CYP2C19 (0.75) | — | |
| Ethylisothiourea SCHEMBL2787239 | 0.84 | NOS1 (0.75) | — | |
| Ethylisothiourea SCHEMBL11693925 | 0.78 | NOS1 (0.65) | — | |
| Bromide SCHEMBL31317494 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 345 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117285600-A | Synthesis method of ganirelix acetate | 翰宇药业（武汉）有限公司 | 2023-12-26 | — | — | CN | claimed |
| CN-115926563-B | Preparation method and application of high-strength composite antibacterial aluminum foil coating | 万华化学集团股份有限公司 | 2023-09-19 | — | — | CN | claimed |
| CN-115926563-A | Preparation method and application of high-strength composite antibacterial aluminum foil coating | 万华化学集团股份有限公司 | 2023-04-07 | — | — | CN | claimed |
| CN-110194826-B | Modified polysiloxane and application thereof | 广东工业大学 | 2021-10-26 | — | — | CN | claimed |
| CN-110194829-B | Preparation method of high-refractive-index PU (polyurethane) modified polysiloxane | 广东工业大学 | 2021-10-26 | — | — | CN | claimed |
| CN-113493219-A | Tin dioxide quantum dot material, preparation method thereof and photoelectric device | 香港理工大学深圳研究院 | 2021-10-12 | — | — | CN | claimed |
| US-20210299334-A1 | Poly(allylguanidine) and the manufacturing process and the use thereof | NATIONAL TAIWAN UNIVERSITY (TW) | 2021-09-30 | — | — | US | claimed |
| CN-110485165-B | Preparation and application of functionalized polyhedral oligomeric silsesquioxane modified polymer composite coating with specific enrichment function | 福州大学 | 2021-06-29 | — | — | CN | claimed |
| CN-111662461-A | Preparation method and application of gelatin guanidino derivative | 上海海洋大学 | 2020-09-15 | — | — | CN | claimed |
| EP-1357952-B1 | METHOD FOR COATING MEDICAL DEVICE SURFACES | MEDTRONIC INC (US) | 2010-09-01 | — | — | EP | claimed |
| EP-1357952-A2 | METHOD FOR COATING MEDICAL DEVICE SURFACES | Medtronic, Inc. (US) | 2003-11-05 | — | — | EP | claimed |
| US-6617142-B2 | Method for attachment of biomolecules to medical device surfaces | MEDTRONIC, INC. | 2003-09-09 | — | — | US | claimed |
| US-20020120333-A1 | Method for coating medical device surfaces | KEOGH JAMES R (US) | 2002-08-29 | — | — | US | claimed |
| WO-2002060505-A2 | METHOD FOR COATING MEDICAL DEVICE SURFACES | MEDTRONIC, INC. (US) | 2002-08-08 | — | — | WO | claimed |
| US-20020001834-A1 | METHOD FOR ATTACHMENT OF BIOMOLECULES TO MEDICAL DEVICE SURFACES | MEDTRONIC, INC. | 2002-01-03 | — | — | US | claimed |
| WO-2000051623-A2 | INHIBITORS OF SERINE PROTEASE ACTIVITY, METHODS AND COMPOSITIONS FOR TREATMENT OF NITRIC OXIDE-INDUCED CLINICAL CONDITIONS | THE TRUSTEES OF UNIVERSITY TECHNOLOGY CORPORATION (US) | 2000-09-08 | — | — | WO | claimed |
| US-6096124-A | Ink compositions | XEROX CORPORATION (US) | 2000-08-01 | — | — | US | claimed |
| US-6033719-A | Method for covalent attachment of biomolecules to surfaces of medical devices | MEDTRONIC, INC. (US) | 2000-03-07 | — | — | US | claimed |
| US-5928916-A | Ionic attachment of biomolecules with a guanidino moiety to medical device surfaces | MEDTRONIC, INC. (US) | 1999-07-27 | — | — | US | claimed |
| US-5925552-A | Method for attachment of biomolecules to medical devices surfaces | MEDTRONIC, INC. (US) | 1999-07-20 | — | — | US | claimed |