Nafimidone

Nafimidone

SCHEMBL1817018

O=C(Cn1ccnc1)c1ccc2ccccc2c1

nearest known ligand 0.66

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALPG P10696 2/20 0.66
ALPI P09923 1/20 0.66
TDP1 Q9NUW8 1/20 0.66
PLAA Q9Y263 1/20 0.66
L3MBTL1 Q9Y468 1/20 0.66
CYP19A1 P11511 6/20 0.61
CYP11B1 P15538 2/20 0.60
CYP11B2 P19099 2/20 0.60
CA12 O43570 1/20 0.55
CA1 P00915 1/20 0.55
CA2 P00918 1/20 0.55
CA3 P07451 1/20 0.55
CA4 P22748 1/20 0.55
CA6 P23280 1/20 0.55
CA5A P35218 1/20 0.55
CA7 P43166 1/20 0.55
CA9 Q16790 1/20 0.55
CA13 Q8N1Q1 1/20 0.55
CA14 Q9ULX7 1/20 0.55
CA5B Q9Y2D0 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nafimidone SCHEMBL29861032 0.99 ALPG (0.67) ALPGALPITDP1PLAAL3MBTL1
Nafimidone SCHEMBL412582 0.99 ALPG (0.67) ALPGALPITDP1PLAAL3MBTL1
Nafimidone SCHEMBL11356554 0.97 ALPG (0.63) ALPGALPITDP1PLAAL3MBTL1
Nafimidone SCHEMBL11355091 0.92 ALPG (0.57) ALPGALPITDP1PLAAL3MBTL1
SCHEMBL11481042 0.87 ALPG (0.68) ALPGALPITDP1PLAAL3MBTL1
Hydrochloric Acid SCHEMBL11190595 0.86 ALPG (0.65) ALPGALPITDP1PLAAL3MBTL1
Hydrochloric Acid SCHEMBL11181980 0.86 ALPG (0.69) ALPGALPITDP1PLAAL3MBTL1
SCHEMBL11474959 0.86 ALPG (0.63) ALPGALPITDP1PLAAL3MBTL1
SCHEMBL11188512 0.86 ALPG (0.63) ALPGALPITDP1PLAAL3MBTL1
SCHEMBL10974263 0.86 ALPG (0.63) ALPGALPITDP1PLAAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 95 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
EP-1175209-A2 USE OF ANTIEPILEPTICS FOR TREATING RESPIRATORY DISORDERS, IN PARTICULAR ASTHMATIC DISORDERS Lomia, Merab (GE) 2002-01-30 EP claimed
WO-2000066096-A2 USE OF ANTIEPILEPTICS FOR TREATING RESPIRATORY DISORDERS, IN PARTICULAR ASTHMATIC DISORDERS LOMIA MERAB (GE) 2000-11-09 WO claimed
US-4150153-A ANTICONVULSANTS, GASTRIC ANTISECRETORY AGENTS SYNTEX (U.S.A.) INC. (US) 1979-04-17 US claimed
CN-109320458-B Diaryl imidazole-containing compound, preparation method and medical application thereof 中国药科大学 2022-05-31 CN disclosed
US-20220047505-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2022-02-17 US disclosed
US-11191719-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2021-12-07 US disclosed
US-20210134398-A1 Combinatorial Chemistry Computational System and Enhanced Selection Method NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2021-05-06 US disclosed
US-10463611-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2019-11-05 US disclosed
EP-0001926-B1 1-(NAPHTHYLETHYL)IMIDAZOLE DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SYNTEX (U.S.A.) INC. (US) 1981-04-29 EP disclosed
US-4246274-A MICROBIOCIDES BAYER AKTIENGESELLSCHAFT (DE) 1981-01-20 US disclosed
EP-0011769-A1 Hydroxyethyl azoles, process for their preparation and their use in medicaments BAYER AG (DE) 1980-06-11 EP disclosed
EP-0001926-A1 1-(Naphthylethyl)imidazole derivatives, their preparation, and pharmaceutical compositions containing them SYNTEX (U.S.A.) INC. (US) 1979-05-16 EP disclosed
US-4150153-A ANTICONVULSANTS, GASTRIC ANTISECRETORY AGENTS SYNTEX (U.S.A.) INC. (US) 1979-04-17 US disclosed
US-4124767-A Imidazolyl-oxime ethers having anti-mycotic and bactericidal activity SIEGFRIED A.G. (CH) 1978-11-07 US disclosed