Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | CCR4 | P51679 | 3/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8512746 | 0.93 | HTT (0.36) | HTTPTPN1MAPTNPC1RAB9A | |
| SCHEMBL1813140 | 0.85 | PTPN1 (0.37) | PTPN1MAPTCYP1A2CYP3A4TSHR | |
| SCHEMBL164608 | 0.80 | TSHR (0.41) | RAB9AHPGDCYP1A2CYP3A4TSHR | |
| SCHEMBL2021919 | 0.80 | MAPT (0.38) | HTTMAPTHTR1ACYP1A2CYP3A4 | |
| SCHEMBL8511775 | 0.78 | PDK2 (0.39) | HTTPTPN1MAPTHTR7HPGD | |
| SCHEMBL165110 | 0.76 | PDK2 (0.40) | PTPN1RAB9AHPGDCYP1A2TSHR | |
| SCHEMBL30125362 | 0.76 | PDK2 (0.40) | PTPN1RAB9AHPGDCYP1A2TSHR | |
| SCHEMBL30175150 | 0.76 | MAPT (0.34) | HTTPTPN1MAPTNPC1RAB9A | |
| SCHEMBL13988230 | 0.76 | MAPT (0.34) | HTTPTPN1MAPTNPC1RAB9A | |
| SCHEMBL1816275 | 0.75 | KDM4E (0.36) | PTPN1MAPTHTR1AHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2494408-B9 | PHOTOCHROMIC MATERIALS | TRANSITIONS OPTICAL INC (US) | 2015-09-02 | — | — | EP | disclosed |
| EP-2494408-B1 | PHOTOCHROMIC MATERIALS | TRANSITIONS OPTICAL INC (US) | 2015-04-15 | — | — | EP | disclosed |
| EP-2494408-A1 | PHOTOCHROMIC MATERIALS | Transitions Optical, Inc. (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011053615-A1 | PHOTOCHROMIC MATERIALS | TRANSITIONS OPTICAL, INC. (US) | 2011-05-05 | — | — | WO | disclosed |