Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 7/20 | 0.57 |
| ▸ | JAK2 | O60674 | 4/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 5/20 | 0.43 |
| ▸ | CSF1R | P07333 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | PAK4 | O96013 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | IGF1R | P08069 | 2/20 | 0.43 |
| ▸ | MET | P08581 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | PRKACA | P17612 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 2/20 | 0.43 |
| ▸ | LTK | P29376 | 2/20 | 0.43 |
| ▸ | GRK5 | P34947 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18176290 | 0.86 | RPS6KB1 (0.72) | RPS6KB1 | |
| SCHEMBL18176396 | 0.86 | RPS6KB1 (0.72) | RPS6KB1 | |
| SCHEMBL18171866 | 0.82 | RPS6KB1 (0.69) | RPS6KB1JAK2AAK1JAK3CSF1R | |
| Hydrochloric Acid SCHEMBL18171865 | 0.82 | RPS6KB1 (0.68) | RPS6KB1JAK2AAK1JAK3CSF1R | |
| SCHEMBL18176367 | 0.77 | RPS6KB1 (0.59) | RPS6KB1 | |
| SCHEMBL18176365 | 0.77 | RPS6KB1 (0.60) | RPS6KB1 | |
| SCHEMBL18176559 | 0.76 | RPS6KB1 (0.61) | RPS6KB1 | |
| SCHEMBL18176399 | 0.75 | RPS6KB1 (0.58) | RPS6KB1 | |
| SCHEMBL18176553 | 0.75 | RPS6KB1 (0.61) | RPS6KB1 | |
| SCHEMBL780600 | 0.74 | ROCK2 (0.42) | RPS6KB1PIM1GRK5ROCK1ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016170163-A1 | SUBSTITUTED QUINOXALINES AND BENZOTRIAZINE P70S6 KINASE INHIBITORS | SENTINEL ONCOLOGY LIMITED (GB) | 2016-10-27 | — | — | WO | disclosed |
| WO-2016170163-A1 | SUBSTITUTED QUINOXALINES AND BENZOTRIAZINE P70S6 KINASE INHIBITORS | SENTINEL ONCOLOGY LIMITED (GB) | 2016-10-27 | — | — | WO | disclosed |