Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18172116 | 0.81 | PDE4B (0.58) | PDE4BMAPK1LMNAPDE4DHPGD | |
| SCHEMBL18172073 | 0.80 | HPGD (0.61) | SCN9ALMNAHPGDMAPTMEN1 | |
| SCHEMBL10556383 | 0.77 | HPGD (0.63) | PDE4BMAPK1LMNAPDE4DHPGD | |
| SCHEMBL6103405 | 0.76 | HPGD (0.75) | PDE4BMAPK1LMNAPDE4DHPGD | |
| SCHEMBL30900068 | 0.76 | PDE4B (0.71) | PDE4BPDE4DHPGDMAPTP2RY12 | |
| SCHEMBL18172258 | 0.76 | SCN9A (0.76) | SCN9AHPGDKMT2AALDH1A1GAA | |
| SCHEMBL18172177 | 0.76 | SCN9A (0.80) | SCN9AHPGDMAPTMEN1KMT2A | |
| SCHEMBL18172143 | 0.76 | SCN9A (0.73) | SCN9AHPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL20551305 | 0.73 | PDE4D (0.50) | PDE4BMAPK1LMNAPDE4DHPGD | |
| SCHEMBL10556670 | 0.72 | MAPK1 (0.53) | PDE4BMAPK1LMNAPDE4DHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286178-A1 | AMINO-SUBSTITUTED HETEROCYCLIC DERIVATIVES AS SODIUM CHANNEL INHIBITORS | Almirall S.A. (ES) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016170009-A1 | AMINO-SUBSTITUTED HETEROCYCLIC DERIVATIVES AS SODIUM CHANNEL INHIBITORS | ALMIRALL, S.A. (ES) | 2016-10-27 | — | — | WO | disclosed |