Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 17/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 17/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 17/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 16/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 16/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 12/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 11/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 11/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 11/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 11/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9895336 | 0.84 | CYP19A1 (0.37) | HDAC8HDAC3HDAC6HDAC4HDAC1 | |
| SCHEMBL7898598 | 0.84 | CYP19A1 (0.37) | HDAC8HDAC3HDAC6HDAC4HDAC1 | |
| Trifluoroacetic Acid SCHEMBL9895577 | 0.79 | HDAC1 (0.35) | HDAC8HDAC3HDAC6HDAC4HDAC1 | |
| SCHEMBL7899904 | 0.71 | CYP19A1 (0.32) | CYP19A1 | |
| SCHEMBL9895036 | 0.71 | CYP19A1 (0.32) | CYP19A1 | |
| SCHEMBL7899161 | 0.65 | HDAC3 (0.42) | HDAC8HDAC3HDAC6HDAC4HDAC1 | |
| SCHEMBL9894988 | 0.63 | HDAC3 (0.41) | HDAC8HDAC3HDAC6HDAC4HDAC1 | |
| SCHEMBL181679 | 0.63 | HDAC3 (0.41) | HDAC8HDAC3HDAC6HDAC4HDAC1 | |
| SCHEMBL181678 | 0.63 | HDAC3 (0.41) | HDAC8HDAC3HDAC6HDAC4HDAC1 | |
| SCHEMBL1411198 | 0.62 | HDAC1 (0.45) | HDAC8HDAC3HDAC6HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401257-A1 | ENZYME INHIBITORS | Chroma Therapeutics Ltd. (GB) | 2012-01-04 | — | — | EP | claimed |
| WO-2010097586-A1 | ENZYME INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2010-09-02 | — | — | WO | claimed |