SCHEMBL18172232

SCHEMBL18172232

Cc1nn(-c2ccccc2Br)c(N)c1C(=O)Nc1ccc(Cl)cn1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 6/20 0.72
WNT3A P56704 2/20 0.53
RAB9A P51151 2/20 0.48
NPC1 O15118 1/20 0.48
ALOX15 P16050 1/20 0.48
HTT P42858 1/20 0.48
RIPK1 Q13546 1/20 0.48
KMT2A Q03164 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
SCN5A Q14524 2/20 0.46
POLB P06746 1/20 0.46
BRD4 O60885 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.45
TP53 P04637 1/20 0.45
TSHR P16473 1/20 0.45
NFKB1 P19838 1/20 0.45
NFKB2 Q00653 1/20 0.45
RELA Q04206 1/20 0.45
ALDH1A1 P00352 2/20 0.44
MAPT P10636 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18172185 0.90 SCN9A (0.75) SCN9AWNT3ARAB9ANPC1ALOX15
SCHEMBL18172222 0.88 SCN9A (0.85) SCN9AWNT3ARAB9ANPC1ALOX15
SCHEMBL18172117 0.86 SCN9A (0.82) SCN9AWNT3ARAB9ANPC1ALOX15
SCHEMBL18172063 0.86 SCN9A (0.70) SCN9ARAB9ANPC1ALOX15HTT
SCHEMBL18172223 0.85 SCN9A (0.81) SCN9AWNT3ARAB9ANPC1SCN5A
SCHEMBL18172137 0.84 SCN9A (0.73) SCN9AWNT3ARAB9ANPC1ALOX15
SCHEMBL18172256 0.84 SCN9A (0.85) SCN9AWNT3ARAB9ANPC1ALOX15
SCHEMBL18172195 0.84 SCN9A (1.00) SCN9AWNT3ARAB9ANPC1ALOX15
SCHEMBL18172274 0.78 SCN9A (0.76) SCN9AWNT3ARAB9ANPC1ALOX15
SCHEMBL18171995 0.78 SCN9A (0.76) SCN9AWNT3ARAB9ANPC1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3286178-A1 AMINO-SUBSTITUTED HETEROCYCLIC DERIVATIVES AS SODIUM CHANNEL INHIBITORS Almirall S.A. (ES) 2018-02-28 EP disclosed
WO-2016170009-A1 AMINO-SUBSTITUTED HETEROCYCLIC DERIVATIVES AS SODIUM CHANNEL INHIBITORS ALMIRALL, S.A. (ES) 2016-10-27 WO disclosed