Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 2/20 | 0.39 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.39 |
| ▸ | P2RY14 | Q15391 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18172501 | 0.91 | P2RX3 (0.37) | P2RX3P2RX2P2RY14MAP3K5LMNA | |
| SCHEMBL18172438 | 0.90 | P2RX3 (0.45) | P2RX3P2RX2P2RY14LMNA | |
| SCHEMBL18172427 | 0.89 | P2RX3 (0.40) | P2RX3P2RX2P2RY14TSHRPTK2 | |
| SCHEMBL18172352 | 0.86 | P2RY14 (0.41) | P2RY14TSHRTDP1DPP4DPP8 | |
| SCHEMBL20533664 | 0.82 | P2RY14 (0.44) | P2RX3P2RX2P2RY14LMNA | |
| SCHEMBL18184305 | 0.82 | P2RX3 (0.37) | P2RX3P2RX2P2RY14MAP3K5POLB | |
| SCHEMBL18172450 | 0.82 | P2RY14 (0.43) | P2RX3P2RX2P2RY14MAP3K5LMNA | |
| SCHEMBL18172486 | 0.81 | P2RX3 (0.37) | P2RX3P2RX2P2RY14TSHRPTK2 | |
| SCHEMBL4331537 | 0.81 | P2RX3 (0.49) | P2RX3P2RX2P2RY14MAP3K5LMNA | |
| SCHEMBL18706296 | 0.81 | TTK (0.37) | P2RX3P2RX2P2RY14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286182-A1 | TETRAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PSYCHIATRIC DISORDERS | F. Hoffmann-La Roche AG (CH) | 2018-02-28 | — | — | EP | claimed |
| WO-2016169902-A1 | TETRAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PSYCHIATRIC DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-10-27 | — | — | WO | claimed |