Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18172504 | 0.92 | TSHR (0.44) | P2RY14NPC1RAB9ATSHRKMT2A | |
| SCHEMBL18172363 | 0.91 | P2RY14 (0.41) | P2RY14NPC1RAB9ATSHRKMT2A | |
| SCHEMBL18172458 | 0.84 | P2RY14 (0.42) | P2RY14NPC1RAB9AATMNPSR1 | |
| SCHEMBL20533433 | 0.83 | P2RY14 (0.44) | P2RY14NPC1RAB9AATMNPSR1 | |
| SCHEMBL18173623 | 0.82 | P2RX3 (0.37) | P2RY14LMNAKMT2ASMN1; SMN2MAPT | |
| SCHEMBL18172442 | 0.81 | P2RX3 (0.39) | P2RY14LMNAKMT2AMAPT | |
| SCHEMBL18172352 | 0.80 | P2RY14 (0.41) | P2RY14NPC1RAB9AATMNPSR1 | |
| SCHEMBL18172460 | 0.79 | P2RY14 (0.62) | P2RY14NPC1RAB9ASMN1; SMN2OPRD1 | |
| SCHEMBL4321393 | 0.77 | TSHR (0.49) | P2RY14NPC1RAB9ATSHRKMT2A | |
| SCHEMBL18172503 | 0.77 | P2RY14 (0.53) | P2RY14NPC1RAB9AOPRD1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286182-A1 | TETRAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PSYCHIATRIC DISORDERS | F. Hoffmann-La Roche AG (CH) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016169902-A1 | TETRAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PSYCHIATRIC DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-10-27 | — | — | WO | disclosed |