Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 14/20 | 0.45 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18172357 | 0.88 | P2RY14 (0.54) | P2RY14OPRD1MCHR1 | |
| SCHEMBL18172428 | 0.88 | PRCP (0.40) | P2RY14PRCPHSD11B1 | |
| SCHEMBL18172351 | 0.86 | CNR1 (0.43) | P2RY14HSD11B1 | |
| SCHEMBL18173388 | 0.86 | P2RX3 (0.44) | P2RY14CCR1OPRD1SIGMAR1PRCP | |
| SCHEMBL20533664 | 0.83 | P2RY14 (0.44) | P2RY14OPRD1SIGMAR1ADRA2AADRA2B | |
| SCHEMBL20533687 | 0.83 | PRCP (0.42) | P2RY14CCR1PRCP | |
| SCHEMBL18184305 | 0.81 | P2RX3 (0.37) | P2RY14HSD11B1 | |
| SCHEMBL20533797 | 0.81 | P2RY14 (0.47) | P2RY14OPRD1SIGMAR1 | |
| SCHEMBL20533465 | 0.81 | P2RX3 (0.38) | P2RY14CCR1 | |
| SCHEMBL18172417 | 0.81 | PRCP (0.38) | P2RY14CCR1PRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286182-A1 | TETRAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PSYCHIATRIC DISORDERS | F. Hoffmann-La Roche AG (CH) | 2018-02-28 | — | — | EP | claimed |
| WO-2016169902-A1 | TETRAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PSYCHIATRIC DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-10-27 | — | — | WO | claimed |