Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 5/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18172550 | 1.00 | KDM1A (0.42) | KDM1AAKR1C3MEN1KMT2AHPGD | |
| SCHEMBL20527449 | 1.00 | KDM1A (0.42) | KDM1AAKR1C3MEN1KMT2AHPGD | |
| SCHEMBL18172547 | 1.00 | KDM1A (0.42) | KDM1AAKR1C3MEN1KMT2AHPGD | |
| SCHEMBL18172553 | 1.00 | KDM1A (0.42) | KDM1AAKR1C3MEN1KMT2AHPGD | |
| SCHEMBL21088706 | 0.83 | MEN1 (0.50) | KDM1AMEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL20527566 | 0.81 | KDM1A (0.35) | KDM1AAKR1C3MEN1KMT2AHPGD | |
| SCHEMBL18173124 | 0.81 | KDM1A (0.35) | KDM1AAKR1C3MEN1KMT2AHPGD | |
| SCHEMBL18173122 | 0.81 | KDM1A (0.35) | KDM1AAKR1C3MEN1KMT2AHPGD | |
| SCHEMBL18173120 | 0.81 | KDM1A (0.35) | KDM1AAKR1C3MEN1KMT2AHPGD | |
| SCHEMBL18173117 | 0.81 | KDM1A (0.35) | KDM1AAKR1C3MEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286172-A1 | LSD1 INHIBITORS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016172496-A1 | LSD1 INHIBITORS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2016-10-27 | — | — | WO | disclosed |