Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18173117 | 1.00 | KDM1A (0.35) | KDM1AHPGDMEN1KMT2AGABRA1 | |
| SCHEMBL18173122 | 1.00 | KDM1A (0.35) | KDM1AHPGDMEN1KMT2AGABRA1 | |
| SCHEMBL20527566 | 1.00 | KDM1A (0.35) | KDM1AHPGDMEN1KMT2AGABRA1 | |
| SCHEMBL18173120 | 1.00 | KDM1A (0.35) | KDM1AHPGDMEN1KMT2AGABRA1 | |
| SCHEMBL18173154 | 0.83 | KDM1A (0.51) | KDM1AAKR1C3ALDH1A1TSHRPKM | |
| SCHEMBL18173156 | 0.83 | KDM1A (0.51) | KDM1AAKR1C3ALDH1A1TSHRPKM | |
| SCHEMBL20527449 | 0.81 | KDM1A (0.42) | KDM1AHPGDMEN1KMT2AAKR1C3 | |
| SCHEMBL18172556 | 0.81 | KDM1A (0.42) | KDM1AHPGDMEN1KMT2AAKR1C3 | |
| SCHEMBL18172550 | 0.81 | KDM1A (0.42) | KDM1AHPGDMEN1KMT2AAKR1C3 | |
| SCHEMBL18172553 | 0.81 | KDM1A (0.42) | KDM1AHPGDMEN1KMT2AAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286172-A1 | LSD1 INHIBITORS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016172496-A1 | LSD1 INHIBITORS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2016-10-27 | — | — | WO | disclosed |