Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18172887 | 1.00 | KDM4E (0.51) | KDM4EPKMKDM1AGPR119MAOA | |
| SCHEMBL18182658 | 0.87 | KDM4E (0.57) | KDM4EPKMKDM1AGPR119TGFBR1 | |
| SCHEMBL18172552 | 0.85 | KDM1A (0.47) | KDM1AMAOA | |
| SCHEMBL18172555 | 0.85 | KDM1A (0.47) | KDM1AMAOA | |
| SCHEMBL10069073 | 0.80 | MAOA (0.52) | KDM4EPKMKDM1AGPR119MAOA | |
| SCHEMBL20015580 | 0.80 | MAOA (0.52) | KDM4EPKMKDM1AGPR119MAOA | |
| SCHEMBL18181850 | 0.78 | KDM4E (0.61) | KDM4EPKMKDM1AGPR119TGFBR1 | |
| SCHEMBL18182587 | 0.76 | KDM1A (0.41) | KDM1AMAOAMAPTSMN1; SMN2 | |
| SCHEMBL19513593 | 0.75 | KDM4E (0.62) | KDM4EPKMKDM1A | |
| SCHEMBL12813368 | 0.75 | KDM4E (0.62) | KDM4EPKMKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286172-A1 | LSD1 INHIBITORS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016172496-A1 | LSD1 INHIBITORS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2016-10-27 | — | — | WO | disclosed |