Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2389984 | 0.84 | ERN1 (0.56) | ERN1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL18173531 | 0.77 | ERN1 (0.43) | ERN1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL2387911 | 0.76 | KDM4E (0.59) | ERN1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL18173535 | 0.74 | ERN1 (0.57) | ERN1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL17471104 | 0.72 | ERN1 (0.45) | ERN1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL2388588 | 0.70 | MAPT (0.64) | ERN1ALDH1A1HPGDKDM4ETSHR | |
| SCHEMBL2389780 | 0.70 | ERN1 (0.57) | ERN1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL2388856 | 0.70 | MAPT (0.53) | ERN1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL2387527 | 0.69 | ERN1 (0.56) | ERN1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL2387255 | 0.69 | ERN1 (0.73) | ERN1ALDH1A1HPGDKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3285760-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | Omeros Corporation (US) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016172573-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORPORATION (US) | 2016-10-27 | — | — | WO | disclosed |