Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.57 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2389984 | 0.89 | ERN1 (0.56) | ERN1SMPD3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2387255 | 0.82 | ERN1 (0.73) | ERN1SMPD3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2389780 | 0.77 | ERN1 (0.57) | ERN1SMPD3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2388588 | 0.77 | MAPT (0.64) | ERN1MEN1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL2388856 | 0.77 | MAPT (0.53) | ERN1SMPD3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL17471104 | 0.76 | ERN1 (0.45) | ERN1SMPD3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL12330908 | 0.76 | ERN1 (0.56) | ERN1SMPD3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2385897 | 0.76 | ERN1 (0.56) | ERN1SMPD3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2387527 | 0.76 | ERN1 (0.56) | ERN1SMPD3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL18173532 | 0.74 | ERN1 (0.43) | ERN1SMPD3MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3285760-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | Omeros Corporation (US) | 2018-02-28 | — | — | EP | disclosed |
| US-9879002-B2 | PDE10 inhibitors and related compositions and methods | OMEROS CORPORATION (US) | 2018-01-30 | — | — | US | disclosed |
| US-9879002-B2 | PDE10 inhibitors and related compositions and methods | OMEROS CORPORATION (US) | 2018-01-30 | — | — | US | disclosed |
| US-9879002-B2 | PDE10 inhibitors and related compositions and methods | OMEROS CORPORATION (US) | 2018-01-30 | — | — | US | disclosed |
| CN-107530313-A | PDE10 inhibitor and compositions related and method | 奥默罗斯公司 | 2018-01-02 | — | — | CN | disclosed |
| US-20170022190-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORPORATION | 2017-01-26 | — | — | US | disclosed |
| US-20170022190-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORPORATION | 2017-01-26 | — | — | US | disclosed |
| WO-2016172573-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORPORATION (US) | 2016-10-27 | — | — | WO | disclosed |
| WO-2016172573-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORPORATION (US) | 2016-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170022190-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | PDE10A, PDE9A, PDE7A | ERN1 4596/4885SMPD3 182/4885MEN1 3164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.