Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | DDX3X | O00571 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18173545 | 0.88 | PDE10A (0.42) | PDE10APDE2APDE5AKDM4EALDH1A1 | |
| SCHEMBL18173590 | 0.87 | PDE10A (0.41) | PDE10APDE2APDE5AKDM4EALDH1A1 | |
| SCHEMBL17232434 | 0.83 | PDE10A (0.54) | PDE10APDE2APDE5AKDM4EALDH1A1 | |
| SCHEMBL2389849 | 0.72 | PDE10A (0.43) | PDE10APDE2APDE5AKDM4EALDH1A1 | |
| SCHEMBL2385799 | 0.71 | MEN1 (0.39) | PDE10APDE2APDE5AKDM4EALDH1A1 | |
| SCHEMBL16707015 | 0.68 | CYP2D6 (0.42) | HSD17B10CYP2C19FAAHCYP2C9 | |
| SCHEMBL17464696 | 0.68 | FAAH (0.36) | PDE10APDE2APDE5AFAAH | |
| SCHEMBL17232419 | 0.67 | PDE10A (0.57) | PDE10APDE2APDE5AKDM4EALDH1A1 | |
| SCHEMBL18859036 | 0.66 | FAAH (0.38) | ALDH1A1FAAH | |
| SCHEMBL18871811 | 0.66 | FAAH (0.38) | FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3285760-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | Omeros Corporation (US) | 2018-02-28 | — | — | EP | disclosed |
| US-9879002-B2 | PDE10 inhibitors and related compositions and methods | OMEROS CORPORATION (US) | 2018-01-30 | — | — | US | disclosed |
| US-9879002-B2 | PDE10 inhibitors and related compositions and methods | OMEROS CORPORATION (US) | 2018-01-30 | — | — | US | disclosed |
| US-9879002-B2 | PDE10 inhibitors and related compositions and methods | OMEROS CORPORATION (US) | 2018-01-30 | — | — | US | disclosed |
| US-20170022190-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORPORATION | 2017-01-26 | — | — | US | disclosed |
| US-20170022190-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORPORATION | 2017-01-26 | — | — | US | disclosed |
| WO-2016172573-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORPORATION (US) | 2016-10-27 | — | — | WO | disclosed |
| WO-2016172573-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORPORATION (US) | 2016-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170022190-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | PDE10A, PDE9A, PDE7A | PDE10A 1/4885PDE2A 9/4885PDE5A 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.