Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 12/20 | 0.44 |
| ▸ | EGFR | P00533 | 5/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | JAK1 | P23458 | 2/20 | 0.44 |
| ▸ | BTK | Q06187 | 4/20 | 0.43 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18173568 | 1.00 | JAK3 (0.44) | JAK3EGFRJAK2JAK1BTK | |
| SCHEMBL18232327 | 0.83 | JAK3 (0.43) | JAK3EGFRJAK2JAK1BTK | |
| SCHEMBL24113542 | 0.83 | JAK3 (0.43) | JAK3EGFRJAK2JAK1BTK | |
| SCHEMBL8362428 | 0.81 | CA12 (0.47) | JAK3EGFRJAK2JAK1BTK | |
| SCHEMBL16802109 | 0.81 | CA12 (0.47) | JAK3EGFRJAK2JAK1BTK | |
| SCHEMBL30208798 | 0.81 | CA12 (0.47) | JAK3EGFRJAK2JAK1BTK | |
| SCHEMBL13067829 | 0.79 | JAK3 (0.42) | JAK3EGFRJAK2JAK1BTK | |
| SCHEMBL17179528 | 0.79 | JAK3 (0.41) | JAK3EGFRJAK2JAK1BTK | |
| SCHEMBL22296413 | 0.79 | JAK3 (0.41) | JAK3EGFRJAK2JAK1BTK | |
| SCHEMBL3487800 | 0.79 | ALDH1A1 (0.54) | JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016170545-A1 | PROCESS FOR THE PREPARATION OF 1-[(3R)-3-[4-AMINO-3-(4-PHENOXYPHENVL)-1H- PVRAZOLO[3,4-D]PYRINIIDIN-1-Y1]-1-PIPERIDINVL]-2-PROPEN-1-ONE AND ITS POLYMORPHS THEREOF | MSN LABORATORIES PRIVATE LIMITED (IN) | 2016-10-27 | — | — | WO | disclosed |