Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.79 |
| ▸ | PKM | P14618 | 2/20 | 0.70 |
| ▸ | RAB9A | P51151 | 3/20 | 0.70 |
| ▸ | NPC1 | O15118 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26597984 | 0.85 | KMT2A (0.74) | MAPTPKMRAB9ANPC1KMT2A | |
| SCHEMBL20777400 | 0.82 | KMT2A (1.00) | MAPTPKMRAB9ANPC1KMT2A | |
| SCHEMBL29188512 | 0.80 | KMT2A (0.69) | MAPTPKMRAB9ANPC1KMT2A | |
| SCHEMBL10008213 | 0.79 | KMT2A (0.70) | MAPTPKMRAB9ANPC1KMT2A | |
| SCHEMBL10008995 | 0.78 | KMT2A (0.71) | MAPTPKMRAB9ANPC1KMT2A | |
| SCHEMBL20773061 | 0.78 | KMT2A (0.70) | MAPTPKMRAB9ANPC1KMT2A | |
| SCHEMBL13875710 | 0.77 | GAA (0.94) | MAPTPKMKMT2AMEN1POLB | |
| SCHEMBL2593770 | 0.77 | KMT2A (0.75) | MAPTPKMRAB9AKMT2AMEN1 | |
| SCHEMBL19018960 | 0.76 | POLB (0.64) | MAPTPKMKMT2AMEN1POLB | |
| SCHEMBL10009399 | 0.75 | KMT2A (0.71) | MAPTPKMRAB9ANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10968183-B2 | Small molecule FIEL1 inhibitor in inflammatory and fibrotic lung injury | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2021-04-06 | — | — | US | disclosed |
| US-10344003-B2 | Small molecule FIEL1 inhibitor in inflammatory and fibrotic lung injury | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2019-07-09 | — | — | US | disclosed |
| US-20180141916-A1 | NOVEL SMALL MOLECULE FIEL1 INHIBITOR IN INFLAMMATORY AND FIBROTIC LUNG INJURY | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-05-24 | — | — | US | disclosed |
| WO-2016172325-A1 | NOVEL SMALL MOLECULE FIEL1 INHIBITOR IN INFLAMMATORY AND FIBROTIC LUNG INJURY | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10344003-B2 | Small molecule FIEL1 inhibitor in inflammatory and fibrotic lung injury | FIP1L1, TRIM28, TFPI2 | MAPT 4203/4885PKM 4293/4885RAB9A 2622/4885 |
| US-20180141916-A1 | NOVEL SMALL MOLECULE FIEL1 INHIBITOR IN INFLAMMATORY AND FIBROTIC LUNG INJURY | FIP1L1, TRIM28, TFPI2 | MAPT 4247/4885PKM 4280/4885RAB9A 2169/4885 |
| US-10968183-B2 | Small molecule FIEL1 inhibitor in inflammatory and fibrotic lung injury | FIP1L1, TRIM28, TFPI2 | MAPT 4203/4885PKM 4293/4885RAB9A 2622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.