TRIM28 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to TRIM28 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Can We Achieve 'high-quality' Weight Loss Through Supplementation and Exercise? the TRIM MUSCLE Study	PHASE3	COMPLETED
Clinical Evaluation of the Effect of Metformin in Sepsis	PHASE3	UNKNOWN
Oral Nitrite for Older Heart Failure Patients	PHASE2	COMPLETED
Efficacy and Safety Assessment of Oral LBH589 in Adult Patients With Advanced Soft TIssue Sarcoma After Pre-treatment Failure	PHASE2	COMPLETED
A Phase Ib/II Clinical Study Evaluating the Safety and Efficacy of Tislelizumab in Combination With Golidocitinib and Selinexor for the Treatment of R/R NKTCL	PHASE1/PHASE2	RECRUITING
Bortezomib for Low or Intermediate-1 Myelodysplastic Syndrome (MDS) With p65 Activation	PHASE2	COMPLETED
Gene Therapy in Treating Patients With Human Immunodeficiency Virus-Related Lymphoma Receiving Stem Cell Transplant	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
Phase I Dose Finding and Proof-of-concept Study of Panobinostat With Standard Dose Cytarabine and Daunorubicin for Untreated Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome	PHASE1	COMPLETED
PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck	PHASE1	COMPLETED
Exploring Novel Biomarkers of ICU-AW in Mechanically Ventilated Children at the Molecular Level	nan	ENROLLING_BY_INVITATION
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract	nan	UNKNOWN
The Role of RING Ubiquitin Ligases in Biologic and Oncologic Processes in Tissues of Mesenchymal Origin	nan	UNKNOWN
RNA Cloning and Visualization in Human Atherosclerosis	nan	COMPLETED
Molecular Profile of the Evolution of Inclusion Body Myositis	nan	COMPLETED
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Novel Intervention to Influence Muscle Plasticity in Veterans	nan	COMPLETED
Genetic Factors Affecting the Severity of Beta Thalassemia	nan	COMPLETED
The Molecular Pathogenesis Study of Cataract	nan	UNKNOWN
EKLF Gene Expression in β-thalassemia	nan	NOT_YET_RECRUITING
Immune Cell Response to Stimuli	nan	RECRUITING
Genetic Determinants of Exercise-Induced Muscle Damage (POLYGENDOMUS)	nan	RECRUITING
Maximizing Mechanisms of Muscle Hypertrophy to Combat Sarcopenia in Older Adults	nan	COMPLETED
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia	nan	UNKNOWN
Selinexor (Nexpovio®) (SVd) in Patients With Relapsed or Refractory Multiple Myeloma	nan	ACTIVE_NOT_RECRUITING
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Studying The Role of Key Epigenetic Mediators in Breast Cancer Patients	nan	RECRUITING
Assessment Of Long Noncoding RNA CCAT1 In Colorectal Cancer Patients	nan	UNKNOWN
ADAR1 Expression Level in Rectal Cancer	nan	RECRUITING
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse	nan	ACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a TRIM28 binder may also engage these)

Protein	Name	Similarity
Q62318	—	1.000	Q62318 →
O08629	—	1.000	O08629 →
Q6ZTA4	—	0.991	Q6ZTA4 →
Q6GQX6	—	0.990	Q6GQX6 →
Q8C0C0	—	0.990	Q8C0C0 →
Q9BQI7	—	0.989	Q9BQI7 →
Q6P1I6	—	0.989	Q6P1I6 →
NR4A1	Nuclear receptor subfamily 4immunitygroup A member 1	0.989	landscape →
Q8VDP4	—	0.989	Q8VDP4 →
Q3TBD2	—	0.989	Q3TBD2 →
Q9NQC1	—	0.988	Q9NQC1 →
MAP3K9	Mitogen-activated protein kinase kinase kinase 9	0.988	landscape →
O70405	—	0.988	O70405 →
Q3U2S4	—	0.988	Q3U2S4 →
A5D7F8	—	0.988	A5D7F8 →
Q8K330	—	0.988	Q8K330 →
A1X157	—	0.988	A1X157 →
Q505D9	—	0.988	Q505D9 →
Q06587	—	0.987	Q06587 →
O95343	—	0.987	O95343 →
Q09YJ3	—	0.987	Q09YJ3 →
Q8WUU4	—	0.987	Q8WUU4 →
Q9BQK8	—	0.987	Q9BQK8 →
O08919	—	0.987	O08919 →
Q9P202	—	0.987	Q9P202 →
Q6ZRF8	—	0.987	Q6ZRF8 →
Q9UFB7	—	0.987	Q9UFB7 →
O54967	—	0.987	O54967 →
RXRB	Retinoic acid receptor RXR-beta	0.987	landscape →
Q9VLW2	—	0.987	Q9VLW2 →