Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.60 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18593556 | 0.96 | NFE2L2 (0.58) | NFE2L2HCAR2TNFKEAP1ALDH1A1 | |
| SCHEMBL18174426 | 0.96 | NFE2L2 (0.58) | NFE2L2HCAR2TNFKEAP1ALDH1A1 | |
| SCHEMBL18174422 | 0.94 | NFE2L2 (0.67) | NFE2L2HCAR2TNFKEAP1KDM4E | |
| SCHEMBL18174424 | 0.94 | NFE2L2 (0.67) | NFE2L2HCAR2TNFKEAP1KDM4E | |
| SCHEMBL18174425 | 0.90 | NFE2L2 (0.65) | NFE2L2HCAR2TNFKEAP1 | |
| SCHEMBL18174428 | 0.90 | NFE2L2 (0.65) | NFE2L2HCAR2TNFKEAP1 | |
| SCHEMBL18593554 | 0.89 | NFE2L2 (0.60) | NFE2L2HCAR2TNFKEAP1 | |
| SCHEMBL18174454 | 0.85 | NFE2L2 (0.58) | NFE2L2HCAR2TNFKEAP1 | |
| SCHEMBL18174459 | 0.85 | NFE2L2 (0.58) | NFE2L2HCAR2TNFKEAP1 | |
| SCHEMBL18174419 | 0.84 | NFE2L2 (0.65) | NFE2L2HCAR2TNFKEAP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9475781-B2 | Fumarate analogs and uses thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2016-10-25 | — | — | US | disclosed |