Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 18/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.56 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.56 |
| ▸ | FECH | P22830 | 1/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.56 |
| ▸ | CLK1 | P49759 | 1/20 | 0.56 |
| ▸ | GSK3A | P49840 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.56 |
| ▸ | MELK | Q14680 | 1/20 | 0.56 |
| ▸ | MYLK3 | Q32MK0 | 1/20 | 0.56 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.56 |
| ▸ | TP53RK | Q96S44 | 1/20 | 0.56 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.54 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.54 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.49 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15641288 | 0.93 | MTOR (0.69) | MTORPIK3CAPIK3CDPIK3CGPIK3C3 | |
| SCHEMBL15641465 | 0.89 | MTOR (0.55) | MTORPIK3CAPIK3CDPIK3CGPIK3C3 | |
| SCHEMBL7922710 | 0.88 | MTOR (0.71) | MTORPIK3CAPIK3CDPIK3CGPIK3C3 | |
| SCHEMBL18174475 | 0.88 | PIK3CA (0.57) | MTORPIK3CAPIK3CDPIK3CGPIK3C3 | |
| SCHEMBL6874822 | 0.82 | MTOR (0.83) | MTORPIK3CAPIK3CDPIK3CGPIK3C3 | |
| SCHEMBL7920902 | 0.81 | MTOR (0.70) | MTORPIK3CAPIK3CDPIK3CGPIK3C3 | |
| SCHEMBL14239211 | 0.81 | MTOR (0.65) | MTORPIK3CAPIK3CDPIK3CGPIK3C3 | |
| SCHEMBL14240434 | 0.81 | MTOR (0.63) | MTORPIK3CAPIK3CDPIK3CGPIK3C3 | |
| SCHEMBL18174472 | 0.81 | MTOR (0.63) | MTORPIK3CAPIK3CDPIK3CGPIK3C3 | |
| SCHEMBL6877963 | 0.81 | MTOR (0.76) | MTORPIK3CAPIK3CDPIK3CGPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9475812-B2 | Pyridonaphthyridine type dual PI3K and mTOR inhibitor and its preparation and use | Xuanzhu Pharma Co., Ltd. (CN) | 2016-10-25 | — | — | US | disclosed |