Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTCH1 | P46531 | 10/20 | 0.48 |
| ▸ | NOTCH3 | Q9UM47 | 7/20 | 0.48 |
| ▸ | RBPJ | Q06330 | 3/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.42 |
| ▸ | STK10 | O94804 | 1/20 | 0.41 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | RORB | Q92753 | 3/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17030705 | 0.87 | NOTCH1 (0.47) | NOTCH1NOTCH3RBPJSTK10SLK | |
| SCHEMBL15631538 | 0.86 | NOTCH1 (0.58) | NOTCH1NOTCH3RBPJ | |
| SCHEMBL15622249 | 0.86 | NOTCH1 (0.58) | NOTCH1NOTCH3RBPJ | |
| SCHEMBL15608316 | 0.85 | NOTCH1 (0.55) | NOTCH1NOTCH3RBPJALDH1A1HPGD | |
| SCHEMBL15622381 | 0.84 | NOTCH1 (0.49) | NOTCH1NOTCH3RBPJALDH1A1 | |
| SCHEMBL15622403 | 0.84 | NOTCH1 (0.49) | NOTCH1NOTCH3RBPJALDH1A1 | |
| SCHEMBL15608340 | 0.84 | NOTCH1 (0.56) | NOTCH1NOTCH3RBPJSTK10SLK | |
| SCHEMBL17030701 | 0.83 | NOTCH1 (0.46) | NOTCH1NOTCH3RBPJ | |
| SCHEMBL15608394 | 0.82 | NOTCH1 (0.61) | NOTCH1NOTCH3RBPJSTK10SLK | |
| SCHEMBL15629441 | 0.82 | NOTCH1 (0.61) | NOTCH1NOTCH3RBPJSTK10SLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897947-B1 | ALKYL, FLUOROALKYL-1,4-BENZODIAZEPINONE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2016-10-26 | — | — | EP | disclosed |