Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTCH1 | P46531 | 8/20 | 0.61 |
| ▸ | NOTCH3 | Q9UM47 | 5/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.39 |
| ▸ | RBPJ | Q06330 | 3/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | STK10 | O94804 | 1/20 | 0.34 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15608394 | 1.00 | NOTCH1 (0.61) | NOTCH1NOTCH3TSHRSMN1; SMN2KDM1A | |
| SCHEMBL15629602 | 0.85 | NOTCH1 (0.57) | NOTCH1NOTCH3KDM1ARBPJSTK10 | |
| SCHEMBL15608442 | 0.85 | NOTCH1 (0.57) | NOTCH1NOTCH3KDM1ARBPJSTK10 | |
| SCHEMBL18174929 | 0.82 | NOTCH1 (0.48) | NOTCH1NOTCH3SMN1; SMN2RBPJSTK10 | |
| SCHEMBL23197996 | 0.77 | NOTCH1 (0.66) | NOTCH1NOTCH3RBPJ | |
| SCHEMBL29412714 | 0.77 | NOTCH1 (1.00) | NOTCH1NOTCH3RBPJ | |
| SCHEMBL15608342 | 0.77 | NOTCH1 (1.00) | NOTCH1NOTCH3RBPJ | |
| SCHEMBL15608343 | 0.77 | NOTCH1 (1.00) | NOTCH1NOTCH3RBPJ | |
| SCHEMBL23197997 | 0.77 | NOTCH1 (1.00) | NOTCH1NOTCH3RBPJ | |
| SCHEMBL15622381 | 0.76 | NOTCH1 (0.49) | NOTCH1NOTCH3RBPJ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897945-B1 | BIS(FLUOROALKYL)-1,4-BENZODIAZEPINONE COMPOUNDS AS NOTCH INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-12-21 | — | — | EP | disclosed |
| US-8999918-B2 | Bis(fluoroalkyl)-1,4-benzodiazepinone compounds and prodrugs thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-04-07 | — | — | US | disclosed |
| WO-2014047372-A1 | BIS(FLUOROALKYL)-1,4-BENZODIAZEPINONE COMPOUNDS AS NOTCH INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-03-27 | — | — | WO | disclosed |
| US-20140087992-A1 | BIS(FLUOROALKYL)-1,4-BENZODIAZEPINONE COMPOUNDS AND PRODRUGS THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2014-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140087992-A1 | BIS(FLUOROALKYL)-1,4-BENZODIAZEPINONE COMPOUNDS AND PRODRUGS THEREOF | CNR1, ROR1, RORB | NOTCH1 71/4885NOTCH3 47/4885TSHR 153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.