Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.67 |
| ▸ | MAPT | P10636 | 11/20 | 0.67 |
| ▸ | HTT | P42858 | 9/20 | 0.67 |
| ▸ | LMNA | P02545 | 7/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.67 |
| ▸ | RAB9A | P51151 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.67 |
| ▸ | POLB | P06746 | 3/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.54 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3501797 | 0.84 | KDM4E (0.71) | TP53HPGDKDM4EMAPTHTT | |
| SCHEMBL3501792 | 0.84 | KDM4E (0.71) | TP53HPGDKDM4EMAPTHTT | |
| SCHEMBL8290434 | 0.83 | ALDH1A1 (0.72) | HPGDKDM4EMAPTHTTLMNA | |
| SCHEMBL13549800 | 0.81 | TP53 (0.72) | TP53HPGDKDM4EMAPTHTT | |
| SCHEMBL8290458 | 0.78 | POLB (0.77) | HPGDKDM4EMAPTLMNAKMT2A | |
| SCHEMBL8299837 | 0.78 | TP53 (0.71) | TP53HPGDKDM4EMAPTHTT | |
| SCHEMBL8298432 | 0.75 | ALDH1A1 (0.70) | TP53HPGDKDM4EMAPTLMNA | |
| SCHEMBL645140 | 0.74 | GAA (0.61) | MAPTHTTLMNARAB9ASMN1; SMN2 | |
| SCHEMBL28284552 | 0.73 | KMT2A (0.78) | KDM4EMAPTHTTLMNAKMT2A | |
| SCHEMBL8299828 | 0.73 | TP53 (0.71) | TP53HPGDKDM4EMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3085367-A2 | COMPOSITIONS FOR THE DIAGNOSIS, TREATMENT, AND PREVENTION OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED | Brandeis University (US) | 2016-10-26 | — | — | EP | disclosed |