SCHEMBL1817555

SCHEMBL1817555

O=C(O)c1ccc(OC2CCCCC2)cc1

nearest known ligand 0.70

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 8/20 0.70
ALDH1A1 P00352 2/20 0.64
LMNA P02545 2/20 0.64
PARP10 Q53GL7 1/20 0.64
CASP3 P42574 1/20 0.64
SENP8 Q96LD8 1/20 0.64
SENP6 Q9GZR1 1/20 0.64
TDP1 Q9NUW8 1/20 0.64
FAAH O00519 3/20 0.54
SRD5A1 P18405 1/20 0.54
PDE4A P27815 1/20 0.52
PDE4B Q07343 1/20 0.52
PDE4C Q08493 1/20 0.52
PDE4D Q08499 1/20 0.52
SRD5A2 P31213 2/20 0.52
NPC1 O15118 1/20 0.50
RAB9A P51151 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
MAOB P27338 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1028676 0.98 EPHX2 (0.68) EPHX2ALDH1A1LMNAPARP10CASP3
SCHEMBL11755572 0.94 PARP10 (0.71) EPHX2ALDH1A1LMNAPARP10CASP3
SCHEMBL1977190 0.90 ALDH1A1 (0.70) EPHX2ALDH1A1LMNAPARP10CASP3
SCHEMBL22563077 0.89 EPHX2 (0.63) EPHX2ALDH1A1LMNAPARP10CASP3
SCHEMBL15131945 0.88 PARP10 (0.58) EPHX2ALDH1A1LMNAPARP10CASP3
SCHEMBL11576648 0.87 PARP10 (0.66) EPHX2ALDH1A1LMNAPARP10CASP3
Hydrochloric Acid SCHEMBL6539076 0.87 EPHX2 (0.56) EPHX2ALDH1A1LMNAPARP10CASP3
SCHEMBL13266897 0.85 ALDH1A1 (0.64) EPHX2ALDH1A1LMNAPARP10CASP3
SCHEMBL12431956 0.85 MAOB (0.56) EPHX2ALDH1A1LMNAPARP10CASP3
SCHEMBL19381882 0.84 PARP10 (0.90) EPHX2ALDH1A1LMNAPARP10SENP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260062443-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS ALEXION PHARMA INC (US) 2026-03-05 US disclosed
CN-114085207-B Bruton tyrosine protein kinase inhibitor and application thereof 广州百霆医药科技有限公司 2024-06-25 CN disclosed
WO-2024044098-A2 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS ALEXION PHARMACEUTICALS, INC. (US) 2024-02-29 WO disclosed
US-20240024302-A1 SOLUBLE EPOXIDE HYDROLASE (sEH) INHIBITORS AND DUAL COX/sEH INHIBITORS FOR THE TREATMENT OF ARRHYTHMOGENIC CARDIOMYOPATHY BETH ISRAEL DEACONESS MEDICAL CENTER, INC. 2024-01-25 US disclosed
EP-4216946-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS Achillion Pharmaceuticals, Inc. (US) 2023-08-02 EP disclosed
CN-116437913-A Pharmaceutical compounds for treating complement-mediated disorders 艾其林医药公司 2023-07-14 CN disclosed
WO-2022066774-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS ACHILLION PHARMACEUTICALS, INC. (US) 2022-03-31 WO disclosed
CN-114085207-A Bruton tyrosine protein kinase inhibitor and application thereof 广州百霆医药科技有限公司 2022-02-25 CN disclosed
US-20210179549-A1 CO-CRYSTAL OF SORAFENIB DERIVATIVES AND PROCESS FOR PREPARATION THEREOF EICOSIS, LLC 2021-06-17 US disclosed
CN-108085021-B Liquid crystal aligning agent, liquid crystal alignment film, liquid crystal display element and reaction product JSR株式会社 2021-06-08 CN disclosed
CN-1240713-C New compound FUJISAWA PHARMACEUTICAL CO (JP) 2006-02-08 CN disclosed
EP-0934276-B1 ANTHRANILIC ACID DERIVATIVES AS MULTI DRUG RESISTANCE MODULATORS XENOVA LTD (GB) 2003-12-17 EP disclosed
CN-1296494-A New compound FUJISAWA PHARMACEUTICAL CO (JP) 2001-05-23 CN disclosed
US-6218393-B1 IN THERAPY OF MULTIDRUG RESISTANT CANCERS, FOR EXAMPLE TO POTENTIATE CYTOTOXICITY OF CANCER DRUG XENOVA LIMITED (GB) 2001-04-17 US disclosed
CN-1241181-A Pharmaceutical compounds XENOVA LTD (GB) 2000-01-12 CN disclosed
EP-0934276-A1 ANTHRANILIC ACID DERIVATIVES AS MULTI DRUG RESISTANCE MODULATORS XENOVA LIMITED (GB) 1999-08-11 EP disclosed
WO-1998017648-A1 ANTHRANILIC ACID DERIVATIVES AS MULTI DRUG RESISTANCE MODULATORS XENOVA LIMITED (GB) 1998-04-30 WO disclosed
EP-0161939-B1 ARYLHYDROXAMATES E.R. Squibb & Sons, Inc. (US) 1993-07-21 EP disclosed
US-4607053-A L2POXYGENASE INHIBITORS E. R. SQUIBB & SONS, INC. (US) 1986-08-19 US disclosed
EP-0161939-A2 Arylhydroxamates E.R. Squibb & Sons, Inc. (US) 1985-11-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260062443-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS C9, SSB, C1S EPHX2 3595/4885ALDH1A1 3835/4885LMNA 345/4885
US-20210179549-A1 CO-CRYSTAL OF SORAFENIB DERIVATIVES AND PROCESS FOR PREPARATION THEREOF EPHX1, VKORC1, VKORC1L1 EPHX2 4/4885ALDH1A1 628/4885LMNA 2075/4885
US-20240024302-A1 SOLUBLE EPOXIDE HYDROLASE (sEH) INHIBITORS AND DUAL COX/sEH INHIBITORS FOR THE TREATMENT OF ARRHYTHMOGENIC CARDIOMYOPATHY EPHX1, EPHX2, PTGER1 EPHX2 2/4885ALDH1A1 125/4885LMNA 1215/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.