Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.63 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 3/20 | 0.43 |
| ▸ | UBE2N | P61088 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL806202 | 0.85 | PIK3CD (0.66) | PIK3CDPIK3R1CNR1CNR2 | |
| SCHEMBL787665 | 0.83 | PIK3CD (0.61) | PIK3CDPIK3R1KMT2ACNR1CNR2 | |
| SCHEMBL806116 | 0.82 | PIK3CD (0.60) | PIK3CDPIK3R1CNR1CNR2 | |
| SCHEMBL788962 | 0.81 | PIK3CD (0.69) | PIK3CDPIK3R1KMT2ACNR1CNR2 | |
| SCHEMBL788059 | 0.80 | PIK3CD (0.58) | PIK3CDPIK3R1CNR1CNR2 | |
| SCHEMBL788303 | 0.79 | PIK3CD (0.59) | PIK3CDPIK3R1UBE2NKMT2ACNR1 | |
| SCHEMBL788603 | 0.79 | PIK3CD (0.70) | PIK3CDPIK3R1MAPTKMT2ACNR1 | |
| SCHEMBL788586 | 0.79 | PIK3CD (0.57) | PIK3CDPIK3R1KMT2ACNR1CNR2 | |
| SCHEMBL788491 | 0.79 | PIK3CD (0.57) | PIK3CDPIK3R1RXFP1MAPTCNR1 | |
| SCHEMBL794109 | 0.79 | PIK3CD (0.59) | PIK3CDPIK3R1UBE2NKMT2ACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616469-B1 | 9H-PURINE COMPOUNDS AS PI3K-DELTA INHIBITORS AND METHODS FOR THEIR MANUFACTURE | EXELIXIS INC (US) | 2016-10-26 | — | — | EP | disclosed |