Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.60 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.60 |
| ▸ | CNR1 | P21554 | 12/20 | 0.43 |
| ▸ | CNR2 | P34972 | 10/20 | 0.43 |
| ▸ | AKT1 | P31749 | 2/20 | 0.40 |
| ▸ | AKT2 | P31751 | 2/20 | 0.40 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL787665 | 0.90 | PIK3CD (0.61) | PIK3CDPIK3R1CNR1CNR2NAPEPLD | |
| SCHEMBL788059 | 0.87 | PIK3CD (0.58) | PIK3CDPIK3R1CNR1CNR2 | |
| SCHEMBL806202 | 0.84 | PIK3CD (0.66) | PIK3CDPIK3R1CNR1CNR2NAPEPLD | |
| SCHEMBL794109 | 0.83 | PIK3CD (0.59) | PIK3CDPIK3R1CNR1CNR2NAPEPLD | |
| SCHEMBL806199 | 0.82 | PIK3CD (0.60) | PIK3CDPIK3R1CNR1CNR2 | |
| SCHEMBL806198 | 0.82 | PIK3CD (0.60) | PIK3CDPIK3R1CNR1CNR2 | |
| SCHEMBL788072 | 0.82 | PIK3CD (0.58) | PIK3CDPIK3R1CNR1CNR2NAPEPLD | |
| SCHEMBL18175791 | 0.82 | PIK3CD (0.63) | PIK3CDPIK3R1CNR1CNR2 | |
| SCHEMBL806241 | 0.81 | PIK3CD (0.57) | PIK3CDPIK3R1 | |
| SCHEMBL788225 | 0.81 | PIK3CD (0.56) | PIK3CDPIK3R1CNR1CNR2NAPEPLD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037226-A1 | INHIBITORS OF PI3K-DELTA AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-03-22 | — | — | WO | disclosed |