SCHEMBL18176554

SCHEMBL18176554

Cc1cccc([C@@H](C)Nc2cnc3cc(-c4ncnc5[nH]ncc45)ccc3n2)c1

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RPS6KB1 P23443 19/20 0.58
EGFR P00533 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18176281 0.91 RPS6KB1 (0.69) RPS6KB1
SCHEMBL18176402 0.91 RPS6KB1 (0.69) RPS6KB1
SCHEMBL18176549 0.90 RPS6KB1 (0.72) RPS6KB1
SCHEMBL18176574 0.90 RPS6KB1 (0.72) RPS6KB1EGFR
SCHEMBL18176403 0.90 RPS6KB1 (0.72) RPS6KB1
SCHEMBL18176579 0.88 RPS6KB1 (0.73) RPS6KB1
SCHEMBL18176557 0.88 RPS6KB1 (0.59) RPS6KB1
SCHEMBL18176288 0.85 RPS6KB1 (0.70) RPS6KB1EGFR
SCHEMBL781546 0.79 SOS1 (0.48)
Hydrochloric Acid SCHEMBL16161598 0.78 SOS1 (0.47)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016170163-A1 SUBSTITUTED QUINOXALINES AND BENZOTRIAZINE P70S6 KINASE INHIBITORS SENTINEL ONCOLOGY LIMITED (GB) 2016-10-27 WO disclosed