SCHEMBL18176403

SCHEMBL18176403

C[C@H](Nc1cnc2cc(-c3ncnc4[nH]ncc34)ccc2n1)c1cccc(Cl)c1

nearest known ligand 0.72

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RPS6KB1 P23443 19/20 0.72
DYRK1A Q13627 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18176549 1.00 RPS6KB1 (0.72) RPS6KB1DYRK1A
SCHEMBL18176554 0.90 RPS6KB1 (0.58) RPS6KB1
SCHEMBL18176281 0.90 RPS6KB1 (0.69) RPS6KB1
SCHEMBL18176402 0.90 RPS6KB1 (0.69) RPS6KB1
SCHEMBL18176574 0.89 RPS6KB1 (0.72) RPS6KB1
SCHEMBL18171869 0.88 RPS6KB1 (0.60) RPS6KB1
SCHEMBL18176579 0.88 RPS6KB1 (0.73) RPS6KB1
Hydrochloric Acid SCHEMBL18171870 0.87 RPS6KB1 (0.59) RPS6KB1
SCHEMBL18176288 0.84 RPS6KB1 (0.70) RPS6KB1
SCHEMBL20593762 0.84 RPS6KB1 (1.00) RPS6KB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016170163-A1 SUBSTITUTED QUINOXALINES AND BENZOTRIAZINE P70S6 KINASE INHIBITORS SENTINEL ONCOLOGY LIMITED (GB) 2016-10-27 WO disclosed