Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.53 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9502405 | 0.87 | CISD1 (0.46) | CISD1STSGLAGAASRC | |
| SCHEMBL9053013 | 0.83 | CISD1 (0.50) | CISD1GLAGAATYR | |
| SCHEMBL3022240 | 0.80 | SRC (0.54) | CISD1GAASRCALDH1A1PPARG | |
| SCHEMBL3042573 | 0.78 | STS (0.64) | CISD1STSGLAGAAPTGS2 | |
| SCHEMBL16664708 | 0.75 | STS (0.37) | CISD1STSCYP1A1CYP1B1PPARG | |
| SCHEMBL26116722 | 0.75 | CISD1 (0.90) | CISD1GAAPTGS2ALDH1A1KDM4E | |
| SCHEMBL9958559 | 0.72 | CYP1A1 (0.52) | GAAPTGS2ALDH1A1KDM4ECYP1A1 | |
| SCHEMBL3520079 | 0.70 | CISD1 (0.63) | CISD1GLAGAAPTGS2ALDH1A1 | |
| SCHEMBL9664445 | 0.70 | CA1 (0.60) | CISD1STSGLAGAAALDH1A1 | |
| SCHEMBL21247190 | 0.70 | CISD1 (1.00) | CISD1GAAPTGS2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9758459-B2 | Allosteric modulators of factor XIa as anticoagulant agents | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2017-09-12 | — | — | US | disclosed |
| US-20160311842-A1 | ALLOSTERIC MODULATORS OF FACTOR XIa AS ANTICOAGULANT AGENTS | VIRGINIA COMMONWEALTH UNIVERSITY | 2016-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160311842-A1 | ALLOSTERIC MODULATORS OF FACTOR XIa AS ANTICOAGULANT AGENTS | TFPI, TFPI2, F10 | CISD1 2696/4885STS 495/4885GLA 306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.