Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1817165 | 0.82 | MEN1 (0.41) | MEN1KMT2AMAPTTP53PDE3B | |
| SCHEMBL1817452 | 0.80 | MEN1 (0.40) | MEN1KMT2AMAPTTP53PDE3B | |
| SCHEMBL1819624 | 0.80 | MEN1 (0.40) | MEN1KMT2AMAPTTP53PDE3B | |
| SCHEMBL1819909 | 0.78 | MEN1 (0.40) | MEN1KMT2AMAPTTP53PDE3B | |
| SCHEMBL1816096 | 0.78 | MEN1 (0.38) | MEN1KMT2AMAPTTP53PDE3B | |
| SCHEMBL1818453 | 0.77 | PDE3B (0.39) | MEN1KMT2AMAPTTP53PDE3B | |
| SCHEMBL1819706 | 0.76 | MEN1 (0.43) | MEN1KMT2AMAPTTP53PDE3B | |
| SCHEMBL1819765 | 0.73 | MEN1 (0.43) | MEN1KMT2AMAPTTP53PDE3B | |
| SCHEMBL1820079 | 0.70 | MEN1 (0.40) | MEN1KMT2AMAPTTP53PDE3B | |
| SCHEMBL1819521 | 0.70 | MEN1 (0.40) | MEN1KMT2AMAPTTP53PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011057892-A1 | 2,3-DIHYDROBENZOXAZINE AND 2,3-DIHYDROBENZOTHIAZINE DERIVATES AS HIF-INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES | ELARA PHARMACEUTICALS GMBH (DE) | 2011-05-19 | — | — | WO | claimed |