Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | PGR | P06401 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1819207 | 0.81 | PDE3B (0.39) | PDE3BPDE3AMEN1KMT2APGR | |
| SCHEMBL1819765 | 0.80 | MEN1 (0.43) | PDE3BPDE3AMEN1KMT2APGR | |
| SCHEMBL12818994 | 0.80 | PGR (0.39) | PDE3BPDE3AMEN1KMT2APGR | |
| SCHEMBL1819521 | 0.79 | MEN1 (0.40) | PDE3BPDE3AMEN1KMT2AMAPT | |
| SCHEMBL1820079 | 0.79 | MEN1 (0.40) | PDE3BPDE3AMEN1KMT2APGR | |
| SCHEMBL12818203 | 0.79 | PDE3B (0.37) | PDE3BPDE3AMEN1KMT2APGR | |
| SCHEMBL12818499 | 0.79 | PKM (0.42) | PDE3BPDE3AMEN1KMT2APGR | |
| SCHEMBL12818998 | 0.78 | PKM (0.39) | PDE3BPDE3AMEN1KMT2APGR | |
| SCHEMBL12818498 | 0.78 | PKM (0.41) | PDE3BPDE3AMEN1KMT2AMAPT | |
| SCHEMBL1818424 | 0.77 | MEN1 (0.41) | PDE3BPDE3AMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011057892-A1 | 2,3-DIHYDROBENZOXAZINE AND 2,3-DIHYDROBENZOTHIAZINE DERIVATES AS HIF-INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES | ELARA PHARMACEUTICALS GMBH (DE) | 2011-05-19 | — | — | WO | disclosed |