Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 7/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | ACACA | Q13085 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30267490 | 0.78 | TRPA1 (0.57) | TRPA1MAPTTRPM8TRPV1RXRA | |
| SCHEMBL18188099 | 0.78 | TRPA1 (0.57) | TRPA1MAPTTRPM8TRPV1RXRA | |
| SCHEMBL28597358 | 0.73 | TRPA1 (0.44) | TRPA1MAPTRXRARXRBRXRG | |
| SCHEMBL23927419 | 0.72 | TRPA1 (0.56) | TRPA1MAPTTRPM8TRPV1RXRA | |
| SCHEMBL25452979 | 0.70 | TRPA1 (0.57) | TRPA1MAPTADORA2A | |
| SCHEMBL23000886 | 0.70 | TRPA1 (0.51) | TRPA1MAPTADORA2A | |
| SCHEMBL18299189 | 0.70 | TRPA1 (0.56) | TRPA1MAPTTRPM8TRPV1RXRA | |
| SCHEMBL1286200 | 0.66 | MAPT (0.52) | TRPA1MAPTACACBGAA | |
| SCHEMBL5771889 | 0.66 | TRPA1 (0.50) | TRPA1MAPTACACB | |
| SCHEMBL25452981 | 0.66 | TRPA1 (0.46) | TRPA1MAPTADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288940-A1 | AZABENZIMIDAZOLES AND THEIR USE AS AMPA RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2018-03-07 | — | — | EP | disclosed |
| WO-2016176460-A1 | AZABENZIMIDAZOLES AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-03 | — | — | WO | disclosed |