SCHEMBL18190

SCHEMBL18190

S=C(c1ncc[nH]1)c1ncc[nH]1

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.42
RAB9A P51151 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.40
ALDH1A1 P00352 2/20 0.40
KMT2A Q03164 1/20 0.40
NISCH Q9Y2I1 2/20 0.33
MTOR P42345 1/20 0.33
ADK P55263 1/20 0.33
HTT P42858 1/20 0.32
FDPS P14324 2/20 0.31
KDM4E B2RXH2 1/20 0.31
PDE4A P27815 1/20 0.31
PDE4B Q07343 1/20 0.31
PDE4C Q08493 1/20 0.31
PDE4D Q08499 1/20 0.31
ALOX15 P16050 1/20 0.31
CYP19A1 P11511 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8633945 0.95 KMT2A (0.42) NPC1RAB9ASMN1; SMN2ALDH1A1KMT2A
Acetonitrile SCHEMBL27785774 0.87 NPC1 (0.40) NPC1RAB9ASMN1; SMN2ALDH1A1KMT2A
Dimethyl Sulfoxide SCHEMBL5704214 0.87 NPC1 (0.40) NPC1RAB9ASMN1; SMN2ALDH1A1KMT2A
SCHEMBL4765851 0.82
SCHEMBL1973074 0.82
SCHEMBL30371 0.80
SCHEMBL2127263 0.80
SCHEMBL6420210 0.80
SCHEMBL20742881 0.80
SCHEMBL6208018 0.80

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 5049 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122054806-A Perovskite solar cell modified based on N, N' -thiocarbonyldiimidazole and preparation method 昆明理工大学 2026-05-15 CN claimed
EP-3455234-B1 SECO MACROLIDE COMPOUNDS SELVITA D O O (HR) 2026-04-01 EP claimed
US-12565477-B2 Preparation method for chlorinated compound JIANGSU KANION PHARMACEUTICAL CO., LTD. (CN) 2026-03-03 US claimed
EP-3957640-B1 FXR SMALL MOLECULE AGONIST AND PREPARATION METHOD THEREFOR AND USE THEREOF SHANGHAI INST MATERIA MEDICA CAS (CN) 2025-09-03 EP claimed
US-20250082793-A1 MACROCYCLIC COMPOUNDS AND METHODS OF MAKING THE SAME JANSSEN BIOTECH, INC. 2025-03-13 US claimed
US-12240841-B2 FXR small molecule agonist and preparation method therefor and use thereof SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) 2025-03-04 US claimed
CN-119361222-A Self-repairing termite-proof cable 广州岭南电缆股份有限公司 2025-01-24 CN claimed
CN-119315023-A Preparation method for improving charge and discharge efficiency and cycle performance of silicon-oxygen anode material 扬州纳力新材料科技有限公司 2025-01-14 CN claimed
CN-119241441-A Preparation method and application of imidazoline metal complex 合肥工业大学 2025-01-03 CN claimed
US-12163009-B2 Reinforced biodegradable polymer nanocomposite and method of manufacture thereof TORAPHENE LTD (GB) 2024-12-10 US claimed
US-4357466-A FROM A TOSYLATED DERIVATIVE ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) 1982-11-02 US claimed
EP-0055453-A2 5-(Pyridinyl)-benzimidazole derivatives and preparation STERLING DRUG INC. (US) 1982-07-07 EP claimed
EP-0012170-B1 7-PHENYL-QUINOLIZIDINE DERIVATIVES (I), THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND (I) FOR USE IN TREATING DISEASES F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1982-04-21 EP claimed
US-4317909-A Preparation of 1,3-dihydro-5-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones STERLING DRUG INC. (US) 1982-03-02 US claimed
US-4309537-A Production of imidazo[4,5-b]pyridin-2-ones or thiones STERLING DRUG INC. (US) 1982-01-05 US claimed
EP-0037990-A1 Phenyl quinolizidines, corresponding pharmaceutical preparations, the preparation of the active compounds and corresponding starting compounds F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1981-10-21 EP claimed
EP-0025443-A1 CYANO-UREAS, CYANO-THIOUREAS AND PREPARATION METHODS THEREOF SOCIETE DE RECHERCHES ET DE SYNTHESES ORGANIQUES SA (CH) 1981-03-25 EP claimed
WO-1980001914-A1 CYANO-UREAS,CYANO-THIOUREAS AND PREPARATION METHODS THEREOF RECH & SYNTHESES ORGANIQUES SA (CH) 1980-09-18 WO claimed
EP-0012170-A1 7-Phenyl-quinolizidine derivatives (I), their preparation, pharmaceutical compositions containing them and (I) for use in treating diseases F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1980-06-25 EP claimed
EP-0010418-A1 Antisecretory guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1980-04-30 EP claimed