Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 9/20 | 0.59 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.59 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.59 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.59 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.59 |
| ▸ | BCL6 | P41182 | 3/20 | 0.55 |
| ▸ | BCOR | Q6W2J9 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.54 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.54 |
| ▸ | CACNG8 | Q8WXS5 | 7/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18190682 | 0.84 | BCL6 (0.60) | GRIA1GRIK1GRIA2GRIA3GRIA4 | |
| SCHEMBL21900280 | 0.83 | GRIA1 (0.84) | GRIA1GRIK1GRIA2GRIA3GRIA4 | |
| SCHEMBL18190580 | 0.82 | MAPT (0.61) | GRIA1BCL6BCORMAPTKDM4E | |
| SCHEMBL20838860 | 0.81 | HPGD (0.53) | GRIA1MAPTKDM4EL3MBTL1CACNG8 | |
| SCHEMBL18190511 | 0.80 | GRIA1 (0.57) | GRIA1GRIK1GRIA2GRIA3GRIA4 | |
| SCHEMBL20838851 | 0.80 | HPGD (0.52) | GRIA1L3MBTL1CACNG8MEN1KMT2A | |
| SCHEMBL1095502 | 0.79 | SIRT2 (0.69) | GRIA1GRIK1GRIA2GRIA3GRIA4 | |
| SCHEMBL6254017 | 0.78 | TSHR (0.61) | MAPTKDM4EMEN1KMT2ATSHR | |
| SCHEMBL18190517 | 0.78 | GRIA1 (0.55) | GRIA1GRIK1GRIA2GRIA3GRIA4 | |
| SCHEMBL18190441 | 0.75 | GRIA1 (0.68) | GRIA1MAPTCACNG8TNKS2PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288936-B1 | BENZIMIDAZOLONE AND BENZOTHIAZOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-05-06 | — | — | EP | claimed |
| EP-3288936-A1 | BENZIMIDAZOLONE AND BENZOTHIAZOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2018-03-07 | — | — | EP | disclosed |
| WO-2016176449-A1 | BENZIMIDAZOLONE AND BENZOTHIAZOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-03 | — | — | WO | disclosed |
| WO-2016176449-A1 | BENZIMIDAZOLONE AND BENZOTHIAZOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-03 | — | — | WO | disclosed |