Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 3/20 | 0.84 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.84 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.84 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.84 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.84 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.54 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.54 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | BCL6 | P41182 | 1/20 | 0.46 |
| ▸ | BCOR | Q6W2J9 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RARA | P10276 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18190480 | 0.85 | GRIA1 (0.62) | GRIA1GRIK1GRIA2GRIA3GRIA4 | |
| SCHEMBL18190764 | 0.83 | GRIA1 (0.59) | GRIA1GRIK1GRIA2GRIA3GRIA4 | |
| SCHEMBL18190765 | 0.80 | GRIA1 (0.57) | GRIA1GRIK1GRIA2GRIA3GRIA4 | |
| SCHEMBL1095502 | 0.79 | SIRT2 (0.69) | GRIA1GRIK1GRIA2GRIA3GRIA4 | |
| SCHEMBL4603074 | 0.78 | GRIK1 (0.62) | GRIA1GRIK1GRIA2GRIA3GRIA4 | |
| SCHEMBL18190720 | 0.78 | GRIA1 (0.55) | GRIA1GRIK1GRIA2GRIA3GRIA4 | |
| SCHEMBL12322303 | 0.78 | GRIA1 (0.58) | GRIA1GRIK1GRIA2GRIA3GRIA4 | |
| SCHEMBL13332899 | 0.75 | GRIA1 (0.53) | GRIA1GRIK1GRIA2GRIA3GRIA4 | |
| SCHEMBL18190461 | 0.75 | GRIA1 (0.68) | GRIA1GRIK1GRIA2GRIA3GRIA4 | |
| SCHEMBL2744390 | 0.75 | GRIK1 (0.59) | GRIA1GRIK1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288936-B1 | BENZIMIDAZOLONE AND BENZOTHIAZOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-05-06 | — | — | EP | claimed |