Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18192075 | 0.78 | KCNJ1 (0.35) | KCNJ1KCNH2 | |
| SCHEMBL18192079 | 0.73 | KCNJ1 (0.35) | KCNJ1KCNH2 | |
| SCHEMBL18192073 | 0.73 | KCNJ1 (0.32) | KCNJ1KCNH2 | |
| SCHEMBL18192064 | 0.72 | KCNJ1 (0.37) | KCNJ1KCNH2 | |
| SCHEMBL18192057 | 0.72 | KCNJ1 (0.33) | KCNJ1KCNH2 | |
| SCHEMBL18192083 | 0.72 | KCNJ1 (0.38) | KCNJ1KCNH2 | |
| SCHEMBL15437196 | 0.69 | USP30 (0.48) | KCNJ1KCNH2USP30 | |
| SCHEMBL1514705 | 0.64 | ACACB (0.39) | — | |
| SCHEMBL21855018 | 0.64 | TRPV1 (0.30) | — | |
| SCHEMBL21631653 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2877471-B1 | SPIRO-FUSED PIPERIDINE DERIVATIVES FOR USE AS INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME (US) | 2016-11-02 | — | — | EP | disclosed |