Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 8/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.37 |
| ▸ | UGCG | Q16739 | 4/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1819582 | 1.00 | PIK3CG (0.40) | PIK3CGPIK3CDENPP2UGCGPIK3CA | |
| SCHEMBL1814919 | 0.89 | ENPP2 (0.43) | PIK3CGPIK3CDENPP2PIK3CAPIK3CB | |
| SCHEMBL1817429 | 0.85 | PIK3CG (0.56) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL1817427 | 0.85 | PIK3CG (0.56) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL12004118 | 0.83 | PIK3CG (0.37) | PIK3CGENPP2HTR2AGRM2 | |
| SCHEMBL12019483 | 0.81 | ENPP2 (0.37) | PIK3CGENPP2HTR2AGRM2 | |
| SCHEMBL12003756 | 0.81 | CHKA (0.41) | PIK3CGPIK3CDUGCG | |
| SCHEMBL1813914 | 0.80 | CHKA (0.36) | PIK3CGPIK3CDENPP2UGCGPIK3CA | |
| SCHEMBL1814432 | 0.80 | PIK3CG (0.37) | PIK3CGPIK3CDENPP2PIK3CAPIK3CB | |
| SCHEMBL1816212 | 0.80 | PIK3CG (0.40) | PIK3CGPIK3CDENPP2PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496569-A2 | HETEROCYCLIC DERIVATIVES | MSD Oss B.V. (NL) | 2012-09-12 | — | — | EP | claimed |
| WO-2011051490-A2 | HETEROCYCLIC DERIVATIVES | N.V. ORGANON (NL) | 2011-05-05 | — | — | WO | claimed |
| US-8507521-B2 | Heterocyclic derivatives | Merck Sharp + Dohme B.V. (NL) | 2013-08-13 | — | — | US | disclosed |
| EP-2496569-A2 | HETEROCYCLIC DERIVATIVES | MSD Oss B.V. (NL) | 2012-09-12 | — | — | EP | disclosed |
| US-20120220622-A1 | HETEROCYCLIC DERIVATIVES | MERCK SHARP & DOHME B.V. (NL) | 2012-08-30 | — | — | US | disclosed |
| WO-2011051490-A2 | HETEROCYCLIC DERIVATIVES | N.V. ORGANON (NL) | 2011-05-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220622-A1 | HETEROCYCLIC DERIVATIVES | GRIN2C, GRIN3A, GRIN2D | PIK3CG 4046/4885PIK3CD 3649/4885ENPP2 2659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.