Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 4/20 | 0.48 |
| ▸ | CACNG8 | Q8WXS5 | 3/20 | 0.48 |
| ▸ | PGR | P06401 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18189430 | 0.92 | GRIA1 (0.51) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL18197603 | 0.86 | GRIA1 (0.63) | GRIA1CACNG8PGRAHRPDE3B | |
| SCHEMBL21517890 | 0.84 | GRIA1 (0.54) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL18189455 | 0.82 | GRIA1 (0.54) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL18189503 | 0.80 | GRIA1 (0.55) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL18189501 | 0.79 | GRIA1 (0.48) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL18189539 | 0.78 | PGR (0.53) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL18189515 | 0.77 | GRIA1 (0.68) | GRIA1CACNG8PGRAHRPDE3B | |
| SCHEMBL21533109 | 0.76 | GRIA1 (0.52) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL21812200 | 0.76 | PGR (0.51) | GRIA1CACNG8PGRBRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016176463-A1 | INDOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-03 | — | — | WO | disclosed |