Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 11/20 | 0.44 |
| ▸ | FYN | P06241 | 5/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2493568 | 0.76 | MET (0.55) | DYRK1AMETLRRK2 | |
| SCHEMBL19338457 | 0.70 | MET (0.39) | MET | |
| SCHEMBL2268153 | 0.67 | MET (0.73) | METFYN | |
| SCHEMBL12368875 | 0.67 | MET (0.51) | DYRK1AMETFYNLRRK2 | |
| SCHEMBL2698395 | 0.64 | MET (0.64) | MET | |
| SCHEMBL12224256 | 0.63 | MET (0.46) | DYRK1AMETFYN | |
| SCHEMBL1133726 | 0.63 | MET (0.57) | METFYNLRRK2 | |
| SCHEMBL1133771 | 0.63 | MET (0.60) | METFYNLRRK2 | |
| Hydrochloric Acid SCHEMBL2697873 | 0.63 | MET (0.63) | MET | |
| SCHEMBL2495255 | 0.61 | MET (1.00) | METFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966214-B1 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-02 | — | — | EP | disclosed |