Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 6/20 | 0.56 |
| ▸ | MET | P08581 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11152842 | 0.83 | FYN (0.57) | FYNMETKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL2496343 | 0.77 | MET (0.78) | FYNMETKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL2495116 | 0.75 | MET (0.80) | FYNMETKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL2492967 | 0.74 | MET (0.78) | FYNMETKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL18613329 | 0.72 | FYN (1.00) | FYN | |
| SCHEMBL2499710 | 0.72 | MET (0.78) | FYNMETKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL13888410 | 0.72 | MET (0.78) | FYNMETKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL2266182 | 0.72 | MET (1.00) | FYNMETKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL2494980 | 0.72 | MET (0.49) | FYNMETKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL2499862 | 0.71 | FYN (0.46) | FYNMETKDM4ESMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966214-B9 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-13 | — | — | EP | disclosed |
| EP-1966214-B1 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-02 | — | — | EP | disclosed |