Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 11/20 | 0.55 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.55 |
| ▸ | PDE2A | O00408 | 1/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | PDE1A | P54750 | 1/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.55 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.55 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.55 |
| ▸ | FYN | P06241 | 6/20 | 0.50 |
| ▸ | NQO2 | P16083 | 2/20 | 0.47 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2423083 | 0.85 | MET (0.57) | METPDE3BPDE3APDE2ACHRM2 | |
| SCHEMBL2765074 | 0.79 | KDM4E (0.59) | METPDE3BPDE3APDE2ACHRM2 | |
| SCHEMBL509620 | 0.79 | FYN (0.53) | METPDE3BPDE3APDE2ACHRM2 | |
| SCHEMBL18197886 | 0.78 | MET (0.59) | METPDE3BPDE3APDE2ACHRM2 | |
| SCHEMBL13209254 | 0.77 | MET (0.61) | METPDE3BPDE3APDE2ACHRM2 | |
| SCHEMBL16136542 | 0.77 | MET (0.58) | METPDE3BPDE3APDE2ACHRM2 | |
| SCHEMBL9910509 | 0.72 | MET (1.00) | METPDE3BPDE3APDE2ACHRM2 | |
| SCHEMBL2697990 | 0.72 | MET (1.00) | METPDE3BPDE3APDE2ACHRM2 | |
| SCHEMBL9910130 | 0.72 | MET (1.00) | METPDE3BPDE3APDE2ACHRM2 | |
| SCHEMBL12049101 | 0.72 | MET (0.68) | METPDE3BPDE3APDE2ACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966214-B1 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-02 | — | — | EP | disclosed |